巨大的甲状腺颗粒:在三个有症状的成年人的诊断工作和表征
Rupal I Mehta1,2, Rajiv Mangla3, Rashi I Mehta4,5
1Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA.
International journal of molecular sciences
|July 29, 2023
概括
巨型骨颗粒 (GAG) 是罕见的,大小的病变导致大脑质量或头痛. 组织学揭示了血管和免疫变化,手术切除后症状消失.
科学领域:
- 神经学 神经学
- 病理学 病理学 病理学
- 血管生物学 血管生物学
背景情况:
- 巨型桃体颗粒 (GAG) 是一种罕见且不太了解的持续性病变.
- 它们可以呈现为占用空间的质量或引起慢性症状,如头痛.
研究的目的:
- 记录GAG的临床和解剖特征.
- 为了研究组织学组成和相关的反应性变化.
- 为了将发现与临床表现和手术结果相关联.
主要方法:
- 一系列案例记录了五个新的GAG.
- 对成像 (MRI/CT) 发现的分析.
- 对两个手术切除的GAG标本进行了组织病理学检查.
主要成果:
- GAGs范围为1.1至3.6厘米,在中年成人中呈现质量效应或头痛.
- 图像显示了不规则的状/状结构与硬质结合,导致静脉鼻狭窄.
- 组织学揭示了原蛋白,血管增殖,炎症,泡细胞和淋巴元素;一个病例患有静脉血栓症.
- 手术切除导致两位治疗患者的症状完全消失.
结论:
- 这是第一个详细介绍了与头痛相关的GAG反应性血管和免疫变化的报告.
- 这些发现突出了GAG的复杂病理,包括炎症和血栓形成.
- 需要进一步的研究来了解GAG的起源及其在疾病中的作用.
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