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2-DG 在破碎后调节表面的免疫失衡

Xingchen Liu^1,2,3,4, Shudan Deng^1,2,3,4, Jiaxin Xie^1,2,3,4

¹Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.

International journal of molecular sciences

|July 29, 2023

概括

围植入炎治疗会使表面变化,导致免疫失衡. 一种糖解抑制剂,2-DG,有效地逆转这种炎症,可能有助于骨再生.

科学领域:

生物材料科学生物材料科学
免疫学免疫学免疫学
再生医学是一种再生医学.

背景情况:

周植入炎的治疗包括机械和化学除菌,以消除细菌生物膜.
在除菌后,在表面的骨再生对于周植入炎治疗至关重要.
免疫微环境显著影响骨再生,但其在脱皮表面的作用尚不清楚.

研究的目的:

为了研究由脱皮的表面引起的免疫微环境.
为了评估糖解抑制剂2-DG对调节这种免疫微环境的影响.
通过操纵免疫反应以增强骨质生成来探索围植入炎的潜在治疗策略.

主要方法:

通过生物膜诱导和机械/化学清洁在体外制备的除表面.
共同培养的巨细胞和CD4+ T淋巴细胞在原始和脱的表面上.
评估免疫细胞分化和炎症基因表达,有或没有2-DG治疗.

主要成果:

脱碎去除了生物膜,但改变了表面的微形态,而没有改变元素组成.
破碎的表面促进了巨细胞 (M1) 和CD4+ T淋巴细胞 (Th17) 的炎症分化.
0.3毫摩尔的2-DG显著降低了炎症细胞分化和抑制了炎症基因表达.

结论:

经过脱bridement后改变的表面地形会诱导炎症性免疫微环境,尽管去除了生物膜.
这种炎症环境可以通过2-DG在体外有效地逆转.
2-DG治疗创造了一个有利于骨质生成的免疫环境,为周植入炎提供了一种新的治疗方法.

关键词:

骨再生骨再生临床治疗方法临床治疗方法免疫不平衡免疫不平衡骨质发生过程 (osteogenesis)骨免疫调节骨免疫调节周植入体炎 (Peri-implantitis) 是一种疾病,

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