低剂量非向效应和线粒体控制
1Laboratory of Cellular and Molecular Radiobiology, PRISME, UMR CNRS 5822/IN2P3, IP2I, Lyon-Sud Medical School, University Lyon 1, 69921 Oullins, France.
International journal of molecular sciences
|July 29, 2023
概括
电离辐射 (IR) 通过线粒体信号传递诱导非向效应 (NTE),影响旁观者和皮细胞. 线粒体在细胞存活和抗瘤放射治疗结果中起着关键作用.
科学领域:
- 辐射生物学 辐射生物学
- 线粒体生物学 线粒体生物学
- 细胞应激反应的应激反应
背景情况:
- 电离辐射 (IR) 的非向效应 (NTE),以前被认为是低剂量现象,现在在高剂量与抗瘤辐射疗法相关的情况下观察到.
- 红外线诱导细胞内和细胞外信号传输,导致旁观者和腹膜效应.
- 线粒体是细胞应激的核心,产生活性氧物种 (ROS) 并影响能量代谢 (ATP).
研究的目的:
- 审查线粒体在通过电离辐射 (IR) 诱导的非向效应 (NTE) 中的突出作用.
- 探索线粒体功能障碍和信号如何导致旁观者和无眼镜效应.
- 了解这些线粒体驱动的NTE对细胞存活率和抗瘤放射治疗 (RT) 的影响.
主要方法:
- 关于电离辐射 (IR),非向效应 (NTE) 和线粒体功能现有文献的综述.
- 分析涉及IR诱导应激反应的细胞内和细胞外信号通路.
- 专注于线粒体在能量生产,ROS/NOS生成和细胞重组中的作用.
主要成果:
- 电离辐射 (IR) 迅速扰乱线粒体功能,增加能量需求和ROS/NOS生产.
- 线粒体功能障碍会触发细胞重组,包括自,线粒体和细胞循环停止.
- 射线诱导的NTE涉及从辐射细胞中释放的分子媒介,影响旁观者和遥远的细胞,并调节免疫反应.
结论:
- 线粒体是细胞存活和对抗瘤放射治疗 (RT) 的反应的关键决定因素.
- 线粒体驱动的非向效应 (NTE) 有助于诸如hormesis,基因组不稳定性和免疫调节等现象.
- 了解线粒体在NTE中的作用对于优化放射治疗策略至关重要.
关键词:
基因损伤反应 (DDR) 是一种对DNA损伤的反应.这就是ROSOS ROS.适应性反应是一种适应性反应.灭症 (apoptosis) 是一种死亡的过程.旁观者效应就是旁观者效应.癌症 癌症 癌症 癌症 癌症基因组的不稳定性霍尔梅西斯的存在辐射过敏症 (HRS) 是一种原生和适应性免疫反应.电离辐射辐射的电离辐射.低剂量效应的低剂量影响线粒体中的线粒体.非目标效应 (NTEs) 是指非目标效应.辐射疗法 辐射疗法信号传输 信号传输更多相关视频
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