肠道微生物组和微生物组衍生的代谢物在患有末期病的患者中
Takeo Koshida1, Tomohito Gohda1, Takuya Sugimoto2
1Department of Nephrology, Faculty of Medicine, Juntendo University, Bunkyo-ku 113-8421, Tokyo, Japan.
International journal of molecular sciences
|July 29, 2023
概括
慢性病 (CKD) 患者的肠道微生物组变化,特别是血液透析 (HD) 患者的肠道微生物组变化,与尿道毒素 (UTs) 和炎症的增加相关,可能会恶化末期病 (ESKD).
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學.
- 胃肠病学 胃肠病学
背景情况:
- 慢性病 (CKD) 与肠道失调,有机酸减少,炎症和尿素毒素 (UT) 积累有关.
- 这种失生症可能会导致末期病 (ESKD) 的进展.
研究的目的:
- 调查肠道微生物组组成与UT水平或ESKD发育之间的关系.
- 为了将接受血液透析 (HD) 的患者与具有正常功能 (NRF) 的患者进行比较.
主要方法:
- 横截面研究比较了41名HD患者和38名NRF患者.
- 分析包括肠道微生物群,血尿道,炎症标志物和便有机酸.
- 群体之间比较了β多样性,微生物丰度和代谢物水平.
主要成果:
- 在NRF和HD患者之间观察到贝塔多样性,便有机酸,炎症标志物和尿路细胞的显著差异.
- 2型糖尿病和功能状况联合增加了硫酸和硫酸.
- 丰富的 * Negativicutes * 和 * Megamonas * 与 ESKD 发育和 UT 水平有关.
结论:
- 肠道微生物组的组成在NRF和HD患者之间,以及在患有和没有2型糖尿病的HD患者之间有显著差异.
- 患有糖尿病的ESKD患者表现出肠道衍生性尿路瘤的增加,可能与心脏脏疾病和预后不佳有关.
- 准肠道失生症可能为CKD管理提供治疗策略.
相关概念视频
01:28Chronic Kidney Disease III: Interprofessional Care
42
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
42
01:25Chronic Kidney Disease I: Introduction
36
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
36
01:24Chronic Kidney Disease II: Clinical Manifestations
30
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
30
01:17Factors Affecting Renal Clearance: Renal Impairment
119
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
119
01:28Kidney Transplant I: Introduction
29
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
29
01:29Acute Kidney Injury II: Pathophysiology
31
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
31