在动物模型中脑下下出血后的神经性发烧:系统性审查
Ernesto Migliorino1, Francesco Nonino2, Roberto Amici3
1IRCCS Istituto delle Scienze Neurologiche di Bologna, Anesthesia and Neurointensive Care Unit, 40139 Bologna, Italy.
International journal of molecular sciences
|July 29, 2023
概括
在动物模型中,脑下垂下出血 (SAH) 后的神经发作发烧与脑下垂空间的红细胞有关. 自主神经系统和中央腺-1受体在温度调节中起着关键作用.
科学领域:
- 神经科学是一个神经科学.
- 病理生理学 病理生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 副arachnoid出血 (SAH) 可以引起神经性发烧,这是一个复杂的条件,在神经关键患者管理具有挑战性.
- 动物模型提供了对人类SAH病理生理学的见解,特别是有关发烧的发展.
- 了解预后因素和神经性发烧的有效治疗方法至关重要.
研究的目的:
- 系统地审查SAH动物模型中神经性发烧的预后因素和病理生理要素.
- 确定最有效的药理疗法来控制神经性发烧.
- 分析特定生物成分和途径在发烧发作和严重程度中的作用.
主要方法:
- 在2021年8月之前发表的SAH动物模型体内实验研究的系统审查.
- 在Pubmed,Embase和生物科学集合数据库中进行的搜索.
- 使用SYRCLE的工具评估偏差风险;使用没有元分析的合成方法 (SWiM) 分析数据.
主要成果:
- 五项研究符合纳入标准,具有很高的方法异质性.
- 脑下部的红细胞与神经发烧有关;血红蛋白的作用是不确定的.
- 涉及自主神经系统对棕色脂肪组织的内化;中央腺-1受体的激活显示了治疗潜力.
结论:
- 在SAH模型中的神经性发烧主要与红细胞的存在有关,而不是前列腺素.
- 棕色脂肪组织的自主神经系统调节对于发烧的发展至关重要.
- 中央腺-1受体激活可能是神经性发烧的可行的治疗策略.
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