在转录活动灭绝期间,双基鼠和人类卵细胞中的染色体配置
Irina Bogolyubova1, Daniil Salimov2, Dmitry Bogolyubov1
1Institute of Cytology of the Russian Academy of Sciences, 194064 St. Petersburg, Russia.
International journal of molecular sciences
|July 29, 2023
概括
卵细胞染色质的配置,对于化和胚胎发育至关重要,在小鼠和人类之间有所不同. 应用像NSN/SN分类这样的小鼠模型可能有助于评估人类卵细胞的质量.
科学领域:
- 生殖生物学 生殖生物学
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
背景情况:
- 胚芽囊泡 (GV) 卵细胞染色体在介质前期经历了显著的重新排列和转录沉默.
- 异常核周围的染色体配置是哺乳动物卵细胞质量和发育潜力的关键指标.
- 鼠标GV卵细胞根据染色质结构被分为NSN (非包围核体) 或SN (包围核体),这是 oogenesis 重要的过渡过程.
研究的目的:
- 审查和讨论当前对小鼠和人类GV卵细胞中的染色质配置的分类.
- 强调转录活动在卵细胞生长过程中停止的重要性.
- 探索小鼠卵子细胞模型的潜在应用,以改善人类卵子细胞质量评估.
主要方法:
- 对GV卵细胞染色体配置在小鼠和人类的现有文献进行比较分析.
- 对小鼠NSN-SN分类系统的审查及其与人类卵子细胞的相关性.
- 强调转录活动在卵细胞生长和成熟过程中的作用.
主要成果:
- 在小鼠中NSN-SN过渡是成功的半月异位和胚胎发育的关键事件.
- 人类GV卵细胞染色质分类缺乏统一的命名法,导致潜在的差异.
- 鼠标的NSN/SN分类可以作为描述人类GV卵细胞的初步工具.
结论:
- 标准化人类GV卵细胞分类对于准确的质量评估和研究至关重要.
- 了解小鼠卵子中的染色质动态,为人类生殖医学提供了宝贵的见解.
- 弥合分类系统的差距可以提高小鼠模型的实用性,以提高人类卵细胞的质量.
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