相关实验视频

Updated: Jul 21, 2025

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

性别差异和癌症中的miRNAs表达:对预后和敏感性的影响

Santino Caserta¹, Sebastiano Gangemi², Giuseppe Murdaca^3,4

¹Division of Hematology, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi", University of Messina, Via Consolare Valeria, 98125 Messina, Italy.

International journal of molecular sciences

|July 29, 2023

概括

性差异影响微RNA (miRNA) 表达,影响癌症的发展和治疗. 了解这些取决于性别的机制对于推进癌症治疗和患者的结果至关重要.

科学领域:

生物化学生物化学
遗传学遗传学是一个
在瘤学瘤学.

背景情况:

微RNA (miRNA) 是小的,非编码的RNA分子,对细胞功能至关重要.
表观遗传因素和性别影响miRNA的表达,影响疾病的发病和进展.
在各种癌症中观察到性别特异的miRNA变化,包括固体瘤和血液恶性瘤.

研究的目的:

审查关于miRNA表达的性别差异的科学文献.
探索miRNAs影响癌症发生,自和亡的机制.
突出miRNA在癌症中的失调的临床影响.

主要方法:

关于研究miRNA表达和癌症中的性别差异的文献综述.
对影响miRNA调节的表观遗传机制 (例如,DNA甲基化) 的分析.
检查miRNA在癌细胞迁移,增殖和亡中的作用.

主要成果:

取决于性别的表观遗传修饰,如DNA甲基转移酶-1介导的miR-142高甲基化,与男性更具侵略性的淋巴瘤有关.
激素治疗 (例如雌激素) 可以调节瘤抑制器miRNAs (miR-26a,miR-92,miR-122),在肝细胞癌中诱导亡.
有证据表明,不同瘤类型的性别,miRNA表达和癌症之间存在广泛的相关性.

结论:

性别是miRNA表达及其在癌症中的作用的重要因素.
针对性别特定的miRNA路径可能为癌症提供新的治疗策略.
对于个性化癌症治疗,需要进一步研究以性别为依赖的方式对miRNA调节和功能的研究.

关键词:

一个X染色体不活化.灭症 (apoptosis) 是一种死亡的过程.癌症癌症癌症癌症癌症表观遗传学是指表观遗传学.一个女人,一个女人,一个女人.基因组印记是基因组的印记.一个男的男的男的男的男的男这是一个小RNARNA.在Mirco上性别差异的性别差异.

更多相关视频

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.