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过敏原特异性免疫疗法对犬类无氧皮肤炎的转录基因变化的影响

Alicja Majewska¹, Małgorzata Gajewska¹, Kourou Dembele²

¹Department of Physiological Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences (SGGW), Nowoursynowska 159, 02-776 Warsaw, Poland.

International journal of molecular sciences

|July 29, 2023

概括

过敏原特异性免疫疗法 (ASIT) 通过改变免疫细胞中的基因表达,有效地修改了犬类亚型皮肤炎 (cAD). 在接受ASIT治疗的cAD狗中,一些基因表达变化恢复到健康狗中所见的水平.

科学领域:

免疫学免疫学免疫学
遗传学是一个遗传学.
兽医医学兽医医学兽医医学

背景情况:

狗性皮肤炎 (cAD) 是一种具有遗传基础的慢性性皮肤疾病.
过敏原特异性免疫疗法 (ASIT) 是唯一对过敏的疾病修饰治疗方法.
在ASIT期间了解免疫系统的变化对于管理cAD至关重要.

研究的目的:

分析接受ASIT的cAD患者外周血液核细胞的基因表达变化.
为了确定在cAD.ASIT期间参与免疫反应调节的特定基因.

主要方法:

在ASIT之前和之后,从cAD狗身上取的血液样本的转录组分析.
治疗cAD犬和健康对照犬之间的基因表达特征的比较.
统计分析以确定差异表达的转录和基因.

主要成果:

鉴定了521个差异表达的转录,其中241个具有已知的功能.
分析了9个被选中的基因 (RARRES2, DPP10, SLPI, PLSCR4, MMP9, NTSR1, CBD103, DEFB122, IL36G) 的表达.
在ASIT后,五个基因 (DPP10,PLSCR4,NTSR1,DEFB122,IL36G) 的表达发生了变化,其中三个基因恢复到了健康的对照水平.

结论:

在cAD患者中,ASIT诱导了基因表达的显著变化.
像DPP10,PLSCR4,NTSR1,DEFB122和IL36G这样的特定基因与ASIT的治疗作用有关.
需要进一步的研究来阐明这些基因在ASIT诱导的免疫耐受性中的作用.

关键词:

过敏原特异性免疫疗法狗类的亚托皮性皮肤炎基因表达的基因表达方式微阵列是一个微阵列.转录组 (transcriptome) 是一个转录组.

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