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八酸骨移植的功能化与西斯普拉丁和佐莱德龙酸:物理化学和生物活性特性
Ekaterina A Kuvshinova1, Nataliya V Petrakova2, Yulia O Nikitina2
1P.A. Herzen Moscow Research Oncology Institute, Branch of FSBI National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, 2nd Botkinsky Pass. 3, 125284 Moscow, Russia.
International journal of molecular sciences
|July 29, 2023
概括
这项研究开发了功能化八酸 (OCP) 骨移植,以局部提供西斯化疗. 这些OCP陶显示了在手术后治疗骨瘤的前景.
科学领域:
- 生物材料科学 生物材料科学
- 在瘤学瘤学.
- 药物输送系统 药物输送系统
背景情况:
- 骨转移是常见的,但药物输送到骨组织是具有挑战性的.
- 需要有针对性的药物输送系统,以便在手术后有效治疗骨瘤.
- 八酸 (OCP) 为局部药物释放提供了一个潜在的平台.
研究的目的:
- 开发一种方法来使OCP骨移植功能化,使用西斯来向本地药物输送.
- 利用zoledronic酸来增强青的结合,并控制其从OCP陶中释放.
- 评估功能化OCP陶在骨缺陷治疗中的有效性和安全性.
主要方法:
- 使用西斯和龙酸对OCP多孔陶颗粒的功能化.
- 使用扫描电子显微镜,光显微镜,HPLC,原子辐射光谱和实时PCR进行表征.
- 在细胞系和动物模型上的体外和体外研究.
主要成果:
- 佐勒多尼酸修改了OCP特性和持续释放西斯.
- 功能化OCP陶证明了生物相容性,骨质导电性和骨质导电性.
- 在体外和体内研究证实了细胞静止和抗瘤作用.
结论:
- 功能化的OCP陶为骨缺陷的局部化疗提供了一个有希望的方法.
- 这种方法增强了切割后初级或转移性骨瘤的治疗效果.
- 开发的材料显示了在骨癌治疗中临床应用的潜力.
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