前性痴呆症,我们在哪里? 一个叙事审查
Annibale Antonioni1,2, Emanuela Maria Raho1, Piervito Lopriore3
1Unit of Clinical Neurology, Neurosciences and Rehabilitation Department, University of Ferrara, 44121 Ferrara, Italy.
International journal of molecular sciences
|July 29, 2023
概括
前性痴呆症 (FTD) 是一种复杂的大脑疾病,影响中年成人. 本综述综合了关于FTD遗传学,诊断和治疗的当前知识,突出了其异质性和影响.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
背景情况:
- 前性痴呆症 (FTD) 是中年痴呆症的重要原因,其特点是前和叶的选择性退化.
- FTD表现出各种症状,包括行为变化,言语障碍和精神问题,对患者和护理人员构成重大负担.
- FTD的极端多样性需要对当前研究进行全面的概述.
研究的目的:
- 提供关于前性痴呆症 (FTD) 病变发生的最新状态审查.
- 将已知发现与遗传学,临床表现和组织病理学的最新进展相结合.
- 探索诊断标准,包括神经成像,核医学,生物标志物和神经生理学研究.
主要方法:
- 审查FTD研究中的既定和最新发现.
- 检查遗传进步及其与临床和病理学特征的关系.
- 诊断工具的分析:神经成像,核医学,生物标志物,脑电图和非侵入性脑刺激.
主要成果:
- 遗传学在FTD中发挥着至关重要的作用,与临床和组织病理学发现以及诸如肌缩性侧面硬化症 (ALS) 等疾病的联系.
- 目前的诊断标准包括神经成像,核医学和液体生物标志物.
- 神经生理学研究提供了对FTD中改变的大脑网络和神经递质系统的见解.
结论:
- 对FTD的全面理解需要整合遗传,临床,病理和诊断数据.
- 神经成像,生物标志物和神经生理学是诊断和理解FTD异质性的关键工具.
- 对当前和实验性疗法的进一步研究对于管理FTD至关重要.
关键词:
C9orf7272 是一个很好的方法.这种行为变体是行为变体.生物标志物 生物标志物前性痴呆症 (FTD) 是一种前性痴呆.神经退行性痴呆症的神经退行性痴呆症不属于阿尔茨海默氏症的痴呆症.主要的渐进性失语症知道了,就知道了.更多相关视频
08:29Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
Published on: December 18, 2016
14.1K
12:04Fluorescence-Activated Cell Sorting-Radioligand Treated Tissue FACS-RTT to Determine the Cellular Origin of Radioactive Signal
Published on: September 10, 2021
2.4K
相关概念视频
01:30Dementia
139
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
139
01:26Alzheimer's Disease: Overview
522
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
522
01:22Alzheimer's Disease: Treatment
218
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
218
01:21Association Areas of the Cortex
5.5K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.5K
01:15Parkinson's Disease: Overview
598
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
598