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尿路长非编码RNA水平作为狼性炎的生物标志物

Cheuk-Chun Szeto^1,2, Ho So¹, Peter Yam-Kau Poon^1,2

¹Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

International journal of molecular sciences

|July 29, 2023

概括

尿路长非编码RNAs (lncRNAs) 显示出作为狼性炎的非侵入性生物标志物的潜力. 特定的 lncRNA 与疾病严重程度和组织学分类相关,有助于诊断和预后.

科学领域:

基因组学和分子生物学
腎臟病學 (nephrology) 是一種醫學.
生物标志物发现发现

背景情况:

长非编码RNAs (lncRNAs) 越来越多地被认为是它们在基因表达中的调节作用.
新出现的证据凸显了 lncRNAs 在各种疾病过程中的潜力.

研究的目的:

研究尿路lncRNAs作为狼性炎的非侵入性生物标志物的实用性.
为了确定尿液中的特定lncRNAs与狼性炎的临床/组织学参数之间的相关性.

主要方法:

从三组狼性炎患者和对照组的尿沉积物的分析.
使用实时定量聚合酶连锁反应量化特定 lncRNA 目标的量化.

主要成果:

尿中母体表达的基因3 (MEG3) 和ANRIL水平与蛋白尿症严重程度相反相关.
尿道癌易感性候选物2 (CASC2) 水平在炎组织学类之间有所不同.
尿转移相关的肺癌转录1 (MALAT1) 与组织学活性指数相关.
尿道 taurine-upregulated gene 1 (TUG1) 水平在狼性炎亚类中显示出明显的模式,并与EGFR相关.

结论:

特定的尿路lncRNAs可以帮助识别狼性炎.
尿路 lncRNA 档案可以预测狼性炎的组织学类.
这些发现支持尿路lncRNAs作为狼性炎的新生物标志物的发展.

关键词:

一个小小的东西.生物标志物生物标志物球体隆基尼弗里斯 (glomerulonephritis) 是一种发生在人体中的疾病.

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