在三级耐火性多发性髓瘤中,贝兰他马布马福多丁单疗法的现实有效性和安全性
Ioannis Ntanasis-Stathopoulos1, Panagiotis Malandrakis1, Despina Fotiou1
1Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 157 72 Athens, Greece.
International journal of molecular sciences
|July 29, 2023
概括
贝兰他马布 (Belantamab mafodotin) 在现实世界多发性骨髓瘤 (MM) 治疗中显示出有效性和耐受性. 对多种疗法耐药的患者获得了显著的生存益处,眼部毒性可控.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 免疫治疗是一种免疫疗法.
背景情况:
- B细胞成熟抗原 (BCMA) 是多发性骨髓瘤 (MM) 的关键点.
- 贝兰他马布 (Belantamab mafodotin) 是一种用于MM治疗的抗BCMA抗体结合剂.
研究的目的:
- 评估贝兰他马布 (Belantamab) 马福多丁单一疗法的现实有效性和耐受性.
- 评估三级耐火性MM患者的结果.
主要方法:
- 对27名三级耐火MM患者的回顾性分析.
- 用贝兰他马布 (Belantamab) 治疗 马福多丁 2.5 毫克/公斤 每 3 周.
- 监测整体反应率 (ORR),疾病控制率 (DCR),无进展生存率 (PFS) 和毒性.
主要成果:
- 的ORR为52%,而DCR为70%.
- 总体而言,PFS的中位数为2个月,响应者为12个月.
- 44%的患者出现了眼睛毒性,其中33.3%的患者患有2-3级角质炎.
结论:
- 在现实MM实践中,Belantamab mafodotin在MM实践中显示出一致的安全性和有效性.
- 在重度预治疗患者中,应答者经历了显著的生存益处.
- 眼睛的毒性是主要问题,需要仔细监测.
关键词:
在 belantamab mafodotin 中使用.结合式的结合式的结合角膜 角膜 角膜 是一个有效性 有效性.这是一种单克隆抗体.多发性骨髓瘤是多发性骨髓瘤的一种.耐火材料 耐火材料 耐火材料这是一个复发的复发.响应 响应 响应 响应在安全方面,安全是安全的.毒性的毒性 毒性的毒性更多相关视频
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