对前列腺癌患者临床显著分子异常的调查:对个性化治疗,预后和遗传检测的影响
Elena Fountzilas1,2, Maria Kouspou3, Alexia Eliades4
1Department of Medical Oncology, St. Lukes's Hospital, 55236 Thessaloniki, Greece.
International journal of molecular sciences
|July 29, 2023
概括
分子分析揭示了61%的欧洲前列腺癌患者的基因变异,其中17.3%具有同类重组修复 (HRR) 基因变异. 这些发现突出了潜在的治疗目标,以及在精准医学领域需要进一步的研究.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 欧洲前列腺癌患者的瘤分子分析数据有限.
- 了解基因变异对于在前列腺癌中推进精准医学至关重要.
研究的目的:
- 评估未经选择的欧洲前列腺癌患者中基因变异的患病率和预后/预测值.
- 为了确定常见的基因变异,特别是在同类重组修复 (HRR) 基因中.
主要方法:
- 使用ForeSENTIA®前列腺面板对196名经组织学确认的前列腺癌患者进行瘤分子分析.
- 针对36个临床相关基因的定向测序和微卫星不稳定性测试.
- 分析的重点是基因变异的流行,特别是在HRR基因中.
主要成果:
- 在120名 (61%) 患者中发现了基因变异.
- 在34名 (17.3%) 患者中发现了HRR基因的改变,其中ATM,BRCA2和BRCA1是最常见的.
- 没有发现HRR基因改变与晚期,年龄,格里森得分或整体存活率之间有显著的关联.
结论:
- 在欧洲前列腺癌患者中存在临床相关的体质基因变异.
- 这些分子变化具有预后意义和潜在的治疗影响.
- 进一步的前性研究是有必要的,以探索这些改变对新疗法的预测作用.
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