纳米纤维素海绵含有抗菌大白提取物
Gabriela Mădălina Oprică1, Denis Mihaela Panaitescu1, Catalina Diana Usurelu1,2
1National Institute for Research and Development in Chemistry and Petrochemistry, 202 Spl. Independentei, 060021 Bucharest, Romania.
International journal of molecular sciences
|July 29, 2023
概括
研究人员使用玄米提取物和粘液开发了抗菌纳米纤维素海绵. 这些新型材料由于其多孔结构和抗菌特性,显示出生物医学应用的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 自然产品化学 自然产品化学
背景情况:
- 纳米纤维素 (NC) 对生物医学用途具有前景,但缺乏固有的抗菌活性.
- 增强NC的抗菌特性对于诸如组织工程和伤口等应用至关重要.
研究的目的:
- 通过结合玄米乙醇提取物 (BE) 和玄米种子粘液 (BSM) 来开发抗菌纳米纤维素海绵.
- 描述所产生的NC/BE和NC/BE/BSM海绵的形态,多孔性,机械强度和抗菌功效.
主要方法:
- 制造纳米纤维素海绵通过冷干燥的NC悬浮剂与不同数量的BE和BSM.
- 使用扫描电子显微镜 (SEM) 进行形态学和微计算机断层扫描以检测毛孔的特征.
- 机械性能 (特定压缩强度) 和抗菌活性对*黄金色菌*的评估.
- 使用L929细胞系评估细胞毒性.
主要成果:
- 所有海绵都表现出开放细胞的纳米纤维结构;更高的BE含量导致了更密集的浸.
- 开放的多孔度从70%到82%不等,由于孔隙填充,随着BE/BSM含量增加而下降.
- 特定压缩强度随着更高的BE含量而增加.
- 在较高的BE度下观察到轻微抑制 *S. aureus* 的生长;没有检测到细胞毒性.
结论:
- 取物和粘液可以成功地赋予纳米纤维素海绵抗菌性质.
- 开发的材料具有适合生物医学应用的孔隙性和机械强度.
- 这些发现强调了一种用于组织工程和药物输送的功能化纳米纤维素的简单方法.
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