在COVID-19后的持续症状和IFN-γ介导途径
Talia Piater1, Mario Gietl1, Stefanie Hofer2
1Department of Internal Medicine II, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Journal of personalized medicine
|July 29, 2023
概括
在COVID-19之后的持续症状,包括疲劳和神经问题,与免疫驱动的氨基酸代谢变化有关,特别是在女性中. 在许多患者中观察到持续的免疫激活和改变的托通路.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢医学是一种代谢医学.
- 后COVID条件 后COVID条件
背景情况:
- 后COVID-19患者经常报告持续的症状,如疲劳,神经问题和失眠.
- 免疫系统的失调和氨基酸代谢的改变是这些长期影响的假设贡献者.
研究的目的:
- 在COVID-19后患有持续症状的患者中调查炎症标志物和氨基酸代谢 (三聚和氨酸).
- 探索这些代谢变化,症状持续性和身体功能之间的关联.
主要方法:
- 对142名患者的横截面分析,大约在急性后60天,PCR证实COVID-19.
- 测量炎症参数 (新丁,C-反应蛋白) 和氨基酸水平/比率 (三聚,氨酸,氨酸,金氨酸).
- 评估症状的持续性 (疼痛,胃肠道问题,厌氧,睡眠障碍,神经症状) 和身体功能.
主要成果:
- 超过48%的患者经历了持续的症状,女性更经常受到影响.
- 炎症标志物 (neopterin,CRP) 的升高和提升的氨酸代谢是常见的.
- 较高的 fenylalanine/tyrosine 比率与女性较低的身体功能相关;与症状改善相关的特定氨基酸变化.
结论:
- 女性在COVID-19后表现出更高的持续症状患病率.
- 肌酸和氨酸代谢的免疫媒介变化与长期症状和减少身体功能有关.
- 这些发现突显了代谢变化在COVID后病理生理学中的作用.
更多相关视频
10:00High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
13.4K
10:10Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
Published on: November 16, 2016
13.7K
相关概念视频
Immune Response Against Viral Pathogens
826
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
826
Stages of Infection
57.0K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
57.0K
Immunological Memory
671
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
671
COPD: Pathogenesis and Clinical Features
349
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
349
Immunodeficiency Diseases
976
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
976
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
