在抑郁症中使用抗抑郁药的药理微生物组学:系统性审查
Lisa C Brown1, William V Bobo2, Cory A Gall3
1Great Scott! Consulting LLC, New York, NY 11222, USA.
Journal of personalized medicine
|July 29, 2023
概括
抗抑郁药可以改变肠道细菌,而这些微生物可能会影响药物的效果. 需要更多的研究来了解这些药物微生物组学 (PMx) 相互作用,以实现个性化的抗抑郁药疗法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
- 神经科学是一个神经科学.
背景情况:
- 肠道微生物组在宿主生理学和药物代谢中起着至关重要的作用.
- 药物与肠道微生物群之间的相互作用越来越被认为对治疗结果很重要.
- 抗抑郁药的药理作用可能受到肠道微生物群落的影响.
研究的目的:
- 系统地审查抗抑郁药物的药物微生物组学 (PMx) 相互作用的现有动物和人类证据.
- 综合关于抗抑郁药如何影响肠道微生物群以及微生物群如何影响抗抑郁药疗效和行为的发现.
- 确定知识上的差距,并指导抗抑郁药PMx.的未来研究方向.
主要方法:
- 在PubMed的系统文献搜索到2022年12月.
- 包括研究研究肠道微生物群对人类和动物模型中抗抑郁药物的作用的影响.
- 根据PRISMA指南进行偏差风险评估和系统审查.
主要成果:
- 包括28项研究 (21项动物,7项人类).
- 发现抗抑郁药会改变肠道微生物群的组成和代谢物.
- 肠道微生物群可以影响抗抑郁药的生物可用性,并可能调节它们的情绪改变作用.
- 大多数研究显示偏差风险中等至高.
结论:
- 有证据表明抗抑郁药,肠道微生物群和行为之间的相互作用.
- 抗抑郁药物药物微生物组学在人类中的临床意义在很大程度上仍未确立.
- 需要进行精心控制的研究来阐明PMx在个性化抗抑郁药物治疗和预测反应中的作用.
相关概念视频
Antidepressant Drugs: Overview
576
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
576
Antidepressant Drugs: MAOIs and Other Agents
275
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
275
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
438
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
438
Long-term Depression
31.0K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
31.0K
Depression: Overview
277
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
277
Depressive Disorders: Etiology
140
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
140


