药物治疗骨关节炎 - - 药丸已经存在吗? 一个叙事审查
Frauke Wilken1, Peter Buschner1, Christian Benignus2
1Department of Orthopedic Surgery and Traumatology, Hospital Barmherzige Brüder Munich, Romanstr. 93, 80639 München, Germany.
Journal of personalized medicine
|July 29, 2023
概括
目前的骨关节炎 (OA) 治疗主要是治疗症状,而不是潜在的疾病. 仍然需要一种因果"药丸"来对抗OA,需要专注于早期检测和针对炎症和代谢途径的新疗法.
科学领域:
- 类风湿病学 类风湿病学
- 药物治疗 药物治疗
- 再生医学是一种再生医学.
背景情况:
- 骨关节炎 (OA) 管理目前依赖于症状治疗,通常涉及疼痛和抗炎药物.
- 这些治疗方法不会改变OA的进展,这是由退行性-再生性失衡引起的.
- 关节置换仍然是典型的末期治疗.
研究的目的:
- 审查目前对骨关节炎的药物治疗选择.
- 评估OA是否存在因果治疗,或者治疗是否仍然主要是症状.
- 讨论未来的治疗方法,包括再生医学和疾病修饰策略.
主要方法:
- 关于骨关节炎药物治疗现有文献的叙述性综述.
- 讨论手术和非手术治疗选择.
- 探索细胞,分子和未来的治疗点.
主要成果:
- 目前对OA的药物治疗主要是症状性,提供疼痛缓解,但不能改变疾病.
- 没有因果关系.
- 药丸与药丸对抗的方法
- 已经建立了OA.
- 人们对再生医学和针对炎症/代谢过程的疗法非常感兴趣,反映了类风湿性关节炎治疗的成功.
结论:
- 骨关节炎治疗在很大程度上是症状性的,缺乏疾病修饰药物.
- 未来的OA治疗应优先考虑通过生物标志物和成像进行早期检测.
- 针对炎症和代谢途径的创新方法对于开发因果疗法至关重要.
相关概念视频
Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
Prescription, Nonprescription and Orphan Drugs
765
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
765
Drug Administration and Therapy Phases: Overview
540
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
540
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
563
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
563


