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在患有重症酸性喘的成年人中,与喘控制不良相关的特征和因素
Clara Padró-Casas1, María Basagaña1, María Luisa Rivera-Ortún2
1Severe Asthma Unit, Allergy Section, Hospital Universitari Germans Trias i Pujol, The Germans Trias i Pujol Research Institute (IGTP), Carretera de Canyet s/n, E-08916 Badalona, Spain.
Journal of personalized medicine
|July 29, 2023
概括
严重的乙酸性喘患者往往患有无法控制的疾病,呼吸道阻塞和年龄较大预测结果不佳. 了解这些因素有助于有效管理严重喘.
科学领域:
- 肺部病理学 肺部病理学
- 过敏和免疫学 过敏和免疫学
- 临床医学 临床医学
背景情况:
- 严重的乙酸性喘影响了大量患者群体,经常出现无法控制的症状.
- 过敏敏感性是普遍存在的,近一半的患者表现出唾液异敏性.
研究的目的:
- 在现实环境中对患有严重酸性喘的成年患者进行表征.
- 在一年的随访后,确定喘预后不佳的预测因素.
主要方法:
- 对98名患有严重酸性喘的成年患者进行了未来1年的随访.
- 临床特征的评估,唾液和血液中异氨基酸的数量,分数呼出的氧化 (FeNO),以及喘控制.
- 多变量分析以确定喘控制不良的独立预测因素.
主要成果:
- 在基线时,87.7%的患者患有不受控制的喘;48.3%患有唾液异敏性.
- 唾液中异氨基酸与外围异氨基酸和FeNO相关.
- 一年后,49%的患者患有持续失控的喘,呼吸道阻塞是主要原因.
- 阻塞性模式 (OR 7.45) 和年龄较大 (OR 1.045) 是控制不良的独立预测因素.
- 在未经控制的成人发作的喘中观察到较高的血清中白素-17 (IL-17) 水平.
结论:
- 呼吸道阻塞和年龄较大是严重酸性喘中喘控制不良的关键预测因素.
- 描述患者的表型,包括eosinophilic和过敏特征,对于管理至关重要.
- 对IL-17等炎症标志物的进一步研究可能为严重喘提供治疗见解.
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