在囊性纤维化中,营养需求的演变
Theresa Frantzen1, Sara Barsky2, Geralyn LaVecchia1
1Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York, NY 11042, USA.
高效调节器疗法 (HEMT) 正在改变囊性纤维化 (CF) 的营养结果,导致不同的健康状况. 这次审查考察了HEMT.
科学领域:
- 医学科学 医学科学 医学科学
- 营养科学 营养科学
- 肺部病理学 肺部病理学
背景情况:
- 囊性纤维化 (CF) 传统上带来了重大的营养挑战.
- 高效调节疗法 (HEMT) 的出现正在改变疾病的自然进展和营养影响.
- 了解这些变化至关重要,因为HEMT现在已被批准用于年轻的儿科患者.
研究的目的:
- 审查有关CF患者不断变化的营养健康状况的当前研究.
- 分析HEMT对CF各种营养和代谢方面的特定影响.
- 提供关于HEMT在CF护理中的长期营养影响的见解.
主要方法:
- 关于CF和HEMT现有研究的综合文献综述.
- 分析有关人体测量,人体构成和能源消耗的研究数据.
- 审查关于胰腺功能,代谢障碍和HEMT治疗CF患者的微量营养素状况的研究.
主要成果:
- HEMT与人体测量和人体构成的显著变化有关.
- 正在观察到对外分泌和内分泌胰腺功能的影响,包括CF相关的糖尿病.
- 注意到维生素和矿物质状况的变化,以及对怀孕和肺移植的考虑.
结论:
- 在CF中,HEMT导致了更异质的营养表型,即使在那些与更糟糕的预后相关的遗传突变患者中也是如此.
- 持续的研究对于充分了解和管理HEMT在整个生命周期的长期营养后果至关重要.
- 个性化的营养策略将越来越重要,以优化CF接受HEMT的个体的健康结果.
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