在COVID-19中的Renin-Angiotensin系统:长期COVID可以预测吗?
Simone König1, Richard Vollenberg2, Phil-Robin Tepasse2
1IZKF Core Unit Proteomics, University of Münster, 48149 Münster, Germany.
Life (Basel, Switzerland)
|July 29, 2023
概括
长期COVID可以通过测量布拉迪基宁 (BK) 血清降解来确定. 这种测试可以检测氨酸-血管素系统 (RAS) 和氨酸-氨酸系统 (KKS) 的调节障碍,这在标准测试中经常错过.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 高血压和心血管疾病增加了严重的COVID-19风险.
- 胺-血管素系统 (RAS) 和卡利克林-胺系统 (KKS) 都与COVID-19的病理生理学有关.
- RAS和KKS的组成部分是COVID-19研究和治疗的目标.
研究的目的:
- 调查布拉迪基宁 (BK) 血清降解是否表明长期COVID.
- 在长期COVID患者中探索BK降解,RAS和KKS失调之间的联系.
主要方法:
- 在患者血清中分析碳氧酶N (CPN) 活性和血管素转化酶 (ACE) 活性.
- 使用标记的布拉迪基宁 (BK) 作为记者来测量血清降解.
- 补充基于质谱的血清蛋白质组分析.
主要成果:
- 在住院和一些康复的COVID-19患者中观察到显著减少的CPN活性和过度的ACE活性.
- 在康复期间,BK血清降解产品在近一半的患者中没有正常化,这表明潜在的RAS失调.
- 长期COVID的标准诊断测试通常会产生正常结果.
结论:
- BK血清降解可能作为长期COVID的生物标志物.
- 测量ACE,血管素II或使用BK降解试验可以帮助识别长期COVID候选人.
- 需要进一步的临床研究来验证这些发现.
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