在低剂量速率前列腺支架疗法后,前列腺癌老年患者下尿道症状的时间变化
Kunihiro Tsuchiya1, Makoto Kawase2, Keita Nakane2
1Department of Urology, General Home Care Clinic, Gifu 5016014, Japan.
Life (Basel, Switzerland)
|July 29, 2023
概括
年长的患者在低剂量率胸膜疗法 (LDR-BT) 后更早地经历了过活性膀症状 (OABSS) 的初始恶化. 治疗前的OABSS预测症状缓解,无论年龄如何.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
背景情况:
- 下尿道症状 (LUTS) 在前列腺癌患者中很常见.
- 低剂量率支臂治疗 (LDR-BT) 是前列腺癌的治疗选择.
- 年龄可能会影响LDR-BT后的症状恢复.
研究的目的:
- 为了比较老年 (≥75岁) 和年轻 (<75岁) 前列腺癌患者LDR-BT后的症状变化.
- 为了评估过度活跃的膀症状评分 (OABSS) 在LDR-BT后按时间顺序进行.
- 在LDR-BT之后识别OABSS解决方案的预测因素.
主要方法:
- 对484名用LDR-BT治疗的前列腺癌患者进行了回顾性研究.
- 评估国际前列腺症状评分 (IPSS),OABSS和IPSS-生活质量 (IPSS-QOL) 在治疗前后.
- 老年人和对照组之间的症状轨迹的比较.
主要成果:
- 老年患者在LDR-BT后1个月显示OABSS增加;对照组在3个月显示增加.
- 从基线到最大OABSS的变化和治疗前OABSS预测延迟OABSS解决.
- 在OABSS解决预测指标中没有观察到与年龄相关的显著差异.
结论:
- 治疗前的OABSS和治疗后的OABSS值是延迟OABSS解析的独立预测指标.
- 没有发现年龄是延迟OABSS解析的重要预测因素.
- 了解这些预测因素可以帮助管理患者的期望和治疗结果.
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