母亲在月经期的年龄 基因多态性与后代的出生体重有关
Yuliya Reshetnikova1, Maria Churnosova1, Vadim Stepanov2
1Department of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, Russia.
Life (Basel, Switzerland)
|July 29, 2023
概括
母亲初潮时的年龄 (AAM) 基因变异与后代的出生体重 (BW) 有关. 这项研究确定了与AAM相关的特定多态和影响新生儿大小的基因相互作用,为发育遗传学提供了洞察力.
科学领域:
- 遗传学 是一个遗传学.
- 生殖生物学 生殖生物学
- 围产儿医学 围产儿医学
背景情况:
- 初潮时的母亲年龄 (AAM) 是一个关键的生殖特征.
- 影响AAM的遗传因素可能会影响后代的发育,包括出生体重 (BW).
- 了解这些遗传关联可以提供关于胎儿生长调节的见解.
研究的目的:
- 调查母体AAM相关单核酸多态 (SNP) 和后代BW之间的关联.
- 确定与BW相关的特定AAM基因变异及其相互作用.
- 探索AAM相关的位置在BW上的功能影响.
主要方法:
- 在716名孕妇及其新生儿中,在AAM候选基因中的50个SNP的基因定型.
- 使用线性回归和基于模型的多因素维度减少 (MB-MDR) 分析SNP与BW的关联.
- 在基生物信息分析以评估已识别的位置的功能相关性.
主要成果:
- 在POMC,KDM3B,INHBA和NKX2-1中,四种AAM相关的基因变异与后代BW有显著的关联.
- 确定了10个SNP间相互作用的显著模型 (pperm ≤0.001) 涉及20个多态.
- 功能分析将22个与AAM相关的SNP和350个代理位点与49个参与激素生物合成和性腺发育的基因联系起来.
结论:
- 母亲AAM相关的基因多态性与后代的出生体重有关.
- 特定的遗传变异及其相互作用在调节胎儿生长方面发挥着作用.
- 这些发现有助于理解出生体重决定因素的遗传基础.
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