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Updated: Jul 21, 2025

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来自罗马尼亚西部的心血管疾病患者的毒菌感染:一个病例对照研究

Angela Dragomir^1,2,3, Maria Alina Lupu^1,2,3,4, Rodica Lighezan^1,3,5

¹Discipline of Parasitology, Department of Infectious Diseases, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Life (Basel, Switzerland)

|July 29, 2023

概括

在罗马尼亚心血管病患者中,毒素菌感染很常见,高血压和不稳定性胸痛患者中发现的发病率更高. 这项研究强调了Toxoplasma gondii和心血管疾病患病率之间的潜在联系.

科学领域:

传染性疾病传染性疾病
心血管流行病学心血管流行病学
寄生虫学的寄生虫学

背景情况:

毒淋巴菌是一种广泛传播的寄生虫,影响着全球人口的很大一部分.
关于T. gondii在心血管病患者队列中的血清流行病学的研究有限.
这项研究通过调查罗马尼亚西部心血管病患者中T. gondii的患病率来弥补一个差距.

研究的目的:

为了确定心血管患者中Toxoplasma gondii抗体的血清流行率.
为了比较心血管病患者和健康的献血者之间的T. gondii血清流行率.
确定T. gondii感染与特定心血管疾病之间的潜在关联.

主要方法:

对T. gondii抗体的血清测试对256名心血管患者和261名匹配的献血者进行.
数据分析包括比较患者和对照组之间的血清流行率.
使用适当的方法评估统计显著性 (p值表示).

主要成果:

总体T. gondii的血清流行率在心血管患者中为64.06%,而在献血者中为52.88%.
在这两组中,血清患病率随着年龄的增长而增加.
与男性献血者 (55.69%;p=0.006) 相比,男性心血管患者 (69.94%) 的T. gondii抗体患病率明显较高.
高血压 (82.35%; p=0.01) 和不稳定的心痛 (67.56%; p=0.02) 显示T. gondii的流行率显著更高.

结论:

这项研究提供了关于罗马尼亚心血管患者T. gondii的新流行病学数据.
在患有高血压和不稳定性心痛的患者中,T. gondii抗体的流行率显著更高.
这些发现表明T. gondii感染与这些心血管疾病之间存在潜在联系,需要进一步调查.

关键词:

罗马尼亚罗马尼亚罗马尼亚罗马尼亚这种毒性淋巴细胞 (Toxoplasma gondii) 是抗体是对抗体的重要组成部分.心血管疾病心血管疾病流行病学流行病学血清发生率的普遍性.

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