儿童潜在的腹腔疾病的特征和短期结果
Michal Kori1,2, Chani Topf-Olivestone3, Firas Rinawi4,5
1Pediatric Gastroenterology, Kaplan Medical Center, Rehovot 5801303, Israel.
Medicina (Kaunas, Lithuania)
|July 29, 2023
概括
儿童潜在的腹腔疾病 (PCD) 在短时间的随访期间很少发展为腹腔疾病 (CeD). 许多患有PCD的儿童表现出正常化或稳定的乳清性血清学,突出显示需要持续监测.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 免疫学 免疫学 免疫学
- 结核病研究 结核病研究
背景情况:
- 潜在的乳性疾病 (PCD) 的特点是阳性乳血清学,没有肠性缩.
- 了解儿童PCD患者在含质饮食中的短期结果对于临床管理至关重要.
研究的目的:
- 描述诊断为潜在病 (PCD) 的儿科患者的短期临床和血清学结果,同时继续食用含饮食 (GCD).
主要方法:
- 在2018年12月至2022年1月期间,对90名儿科PCD患者进行了回顾性分析.
- 基线人口统计,腹血清学 (抗组织转胺酶 - TTG) 和十二指肠活检结果的审查.
- 随访包括重复的血清学和活检,至少12个月或更早诊断患有腹腔疾病 (CeD).
主要成果:
- 在90名儿科PCD患者中,13.3% (12/90) 在随访期间被诊断出患有CeD (平均17.6个月).
- 抗组织转质氨酶 (TTG) 水平在37.8% (34/90) 恢复正常,在53.3% (48/90) 保持稳定.
- 重复内镜检查导致60% (12/20) 的经过该手术的患者诊断出CED.
结论:
- 儿科PCD患者的短期随访显示,CeD的进展率较低 (<15%).
- 很大一部分患者的TTG水平正常化,即使那些最初水平高 (>10xULN) 的患者也是如此.
- 建议对儿科PCD患者进行定期的血清学和组织学监测.
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