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抗菌和防御蛋白在慢性鼻炎与鼻的鼻
Rudolfs Janis Viksne1,2, Gunta Sumeraga1,3, Mara Pilmane4
1Department of Otorhinolaryngology, Riga Stradins University, Pilsonu Street 13, LV-1002 Riga, Latvia.
Medicina (Kaunas, Lithuania)
|July 29, 2023
概括
这项研究发现,慢性鼻炎与鼻 (CRSwNP) 患者的鼻内膜中,关键的抗菌蛋白,人类β-防御素2 (HBD-2),HBD-3和cathelicidin LL-37的水平较低. 这些减少表明屏障功能受损以及在CRSwNP发展中的潜在作用.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 微生物学 微生物学
背景情况:
- 带有鼻息肉的慢性鼻炎 (CRSwNP) 提出了管理方面的挑战.
- 抗微生物和防御蛋白质与CRSwNP的发病有关.
- 调查CRSwNP中的微生物失生症是一个正在进行的研究领域.
研究的目的:
- 在CRSwNP鼻腔粘膜中研究人类β-防御素2 (HBD-2),HBD-3,HBD-4和cathelicidin LL-37的分布和相互联系.
- 为了比较CRSwNP患者的抗微生物水平与健康对照.
主要方法:
- 免疫组织化学分析用于检测HBD-2,HBD-3,HBD-4和LL-37.
- 研究包括48名CRSwNP患者样本 (原发性和复发性息肉) 和17个健康对照样本.
- 样本是在内镜内腔外科手术和隔膜整形期间采集的.
主要成果:
- 与对照组相比,CRSwNP样本上皮质中HBD-2,HBD-3和LL-37显著减少.
- 在初级鼻息肉中,亚皮质HBD-2的水平低于复发性息肉和对照组.
- 与对照组相比,原发性鼻息肉中甲状腺下HBD-3的增加,与LL-37相关.
结论:
- 减少的上皮HBD-2,HBD-3和LL-37表明CRSwNP中的上皮屏障功能受损.
- 降低亚皮质HBD-2可能表明在初级与复发性CRSwNP中对鼻子微生物群的反应不同.
- 升高的亚皮质HBD-3指向了在原发性鼻息肉的发病过程中的潜在作用.
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