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硫酸盐用于腹腔透析患者的石灰治疗:系统性审查
Christy Gossett1, Supawadee Suppadungsuk1,2, Pajaree Krisanapan1,3
1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA.
Medicina (Kaunas, Lithuania)
|July 29, 2023
概括
硫酸盐 (STS) 显示出在腹腔透析 (PD) 患者治疗石灰症的潜力,在各种给药途径上有不同的结果. 需要进一步的研究来优化在PD中STS的使用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 石症是一种严重的疾病,治疗选择有限,特别是在腹膜透析 (PD) 患者中.
- 硫酸盐 (STS) 是一种在血液透析 (HD) 患者中化症的研究治疗方法,但PD患者的数据很少.
研究的目的:
- 系统地审查硫酸盐 (STS) 治疗腹腔透析 (PD) 患者的石灰症的利用和结果.
主要方法:
- 在多个数据库 (Ovid MEDLINE,Cochrane Central,Cochrane系统评论数据库) 进行了系统的文献搜索,直到2022年8月.
- 鉴定和分析了30例PD患者的病例,这些患者通过静脉 (IV),腹腔内 (IP) 或口服途径接受STS治疗.
主要成果:
- 静脉注射STS显示44%的伤口愈合,但50%的死亡率. 内STS显示80%的伤口愈合,但显著的不良影响和20%的死亡率.
- 在两个案例中,口服STS导致了成功的伤口愈合,没有任何不良影响. 然而,结果因服用途径,剂量和持续时间而异.
结论:
- 在PD患者中,硫酸盐 (STS) 治疗结石症的成功率和显著的不良反应取决于给药途径.
- 进一步的研究,包括临床研究和药理动力学数据,对于确定PD患者的最佳STS协议至关重要.
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