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通过皮肤的Flunixin Meglumine作为驴子的止痛药:一个药理动力学试点研究

Amy K McLean^1,2,3, Tara Falt¹, Essam M Abdelfattah^4,5

¹Department of Animal Science, University of California Davis, Davis, CA 95616, USA.

|July 29, 2023

概括

通过皮肤注射的flunixin meglumine (FM) 为驴提供了一种安全的疼痛缓解选择. 这项研究发现,通过皮肤治疗的FM有效降低了炎症生物标志物,与口服或静脉注射途径相比,药物排出速度较慢.

科学领域:

兽医药理学兽医药理学
马类医学马类医学
药理动力学药理动力学

背景情况:

通过皮肤注射的flunixin meglumine (FM) 已被批准用于牛,这表明它可能在其他物种中使用.
驴子可以通过通过皮肤的FM.受益于安全有效的止痛.
了解FM在驴子中的药理动力学和抗炎作用对于非标签应用至关重要.

研究的目的:

为了评估通过皮肤 (TD),口服 (PO) 和静脉注射 (IV) 的flunixin meglumine在驴子中的药理动力学.
评估不同FM给药途径对抗炎生物标志物的影响.
为了确定TD FM对驴子炎症控制的疗效.

主要方法:

一项涉及6只健康驴的三方交叉研究.
使用TD FM (3.3毫克/公斤) 和PO/IV FM (1.1毫克/公斤).
在96小时内采集血液样本,用于LC-MS/MS分析flunixin,5OH flunixin,TXB2和PGF2α.

主要成果:

在TD给药后,flunixin及其代谢物5OH flunixin在血液中可检测到.
与PO和IV相比,TD路线的药物清除速度较慢.
TD FM显著降低了TXB2水平96小时,而PO/IV则降低了8小时.
TD FM显示PGF2α从4小时到72小时逐渐下降,与PO/IV出现的快速减少不同.

结论:

通过皮肤注射的flunixin meglumine在3.3mg/kg是可检测的,并且在驴子中具有长时间的效果.
TD FM显示持续减少炎症生物标志物TXB2和PGF2α.
在标签之外使用3.3毫克/公斤的透皮FM是一种潜在的有效策略,用于管理驴子的炎症.

关键词:

驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子这是eicosanoids.弗鲁尼克辛 (Flunixin) 是一种流的药物.疼痛疼痛疼痛疼痛药物动力学药物动力学药理学药理学药理学药理学药理学通过皮肤的flunixinxin.福利服务福利服务

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