在SLE患者的右心室亚临床功能障碍与代谢指纹和器官损伤相关
Martino Deidda1, Antonio Noto2, Davide Firinu1
1Department of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.
Metabolites
|July 29, 2023
概括
系统性红斑狼 (SLE) 可以导致早期右心室 (RV) 功能障碍,可通过3D心声回声检测. 这种功能障碍与疾病的严重程度,器官损伤和独特的代谢特征相关.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 代谢学 代谢学 代谢学
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性炎症状况,有可能早期引起心脏干扰.
- 右心室 (RV) 功能障碍是SLE的疑似并发症,但早期检测方法和与疾病严重程度的相关性需要进一步调查.
研究的目的:
- 评估SLE患者右心室 (RV) 的3D心声学参数和代谢概况.
- 为了将VR功能和代谢概况与SLE严重程度和累积器官损伤相关联.
主要方法:
- 在40名SLE患者中,使用3D心声扫描来评估RV喷射分数 (RV-EF),隔膜纵向应变 (Septal LS),自由壁纵向应变 (Free-LS) 和分数面积变化 (FAC).
- 进行了代谢分析,以确定与VR功能障碍和SLE严重程度相关的代谢指纹.
- 患者根据系统性狼发疹性疾病活动指数 (SDI) 进行了分层,以分析与疾病损伤的相关性.
主要成果:
- 在TAPSE和RV 3D参数之间发现了直接的相关性.
- 累积损伤较高的患者 (SDI ≥3) 显著减少了FAC,RV-EF, Septal LS和Free-LS.
- RV功能障碍的严重程度与全身器官损伤相关,并且与特定的代谢特征有关,包括2,4-二甲酸,3,4-二甲酸,酸,葡萄糖,谷氨酸,甘氨酸,酸,油酸,酸,尿素和氨酸.
结论:
- 3D回声心力学可以检测SLE患者由于慢性炎症的早期RV功能障碍.
- 在SLE中,RV功能障碍的严重程度与全身器官损伤的程度有关.
- 一个独特的代谢指纹标志着SLE的RV功能障碍,为疾病监测提供了潜在的生物标志物.
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