神经内分泌对儿童代谢综合征风险的影响
Giovanna Scorrano1, Saverio La Bella1, Sara Matricardi1
1Department of Pediatrics, University of Chieti-Pescara, Via Dei Vestini, 66100 Chieti, Italy.
Metabolites
|July 29, 2023
概括
神经内分泌通路对于代谢平衡至关重要. 这些系统中断会增加儿童患代谢综合征 (MetS) 和相关疾病的风险.
科学领域:
- 神经内分泌学神经内分泌学
- 儿科代谢 儿科代谢
- 生理学 生理学 生理学
背景情况:
- 内分泌和神经系统相互作用,以维持平衡.
- 下丘脑是神经内分泌调节新陈代谢过程的中心.
- 神经内分泌路径功能障碍与儿童的代谢综合征 (MetS) 有关.
研究的目的:
- 审查神经内分泌对儿童METS风险的影响.
- 为了确定与神经内分泌路径中断相关的条件.
- 探索儿科 MetS. 的潜在治疗点.
主要方法:
- 文献综述专注于神经内分泌通路和儿童的MetS.
- 对遗传,荷尔蒙和环境因素的分析.
- 检查神经内分泌调节中的反机制.
主要成果:
- 神经内分泌路径异常与脂质不良,肥胖,胰岛素抵抗,2型糖尿病和高血压有关.
- 特定的神经内分泌干扰有助于儿童群体中MetS的发展.
- 关键路径中的遗传或表观遗传突变可能提供治疗点.
结论:
- 神经内分泌系统在儿科MetS的病理生理学中发挥着重要作用.
- 了解神经内分泌干扰对于管理儿童的MetS至关重要.
- 准"热"的神经内分泌通路可能会导致针对严重的儿科MetS的新疗法.
更多相关视频
10:31An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
10.7K
08:47Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
Published on: December 7, 2017
9.8K
相关概念视频
Overview of Carbohydrate Metabolism
1.2K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.2K
Obesity
534
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
534
Psychoneuroimmunology: Diabetes and Cancer
47
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
47
The Endocrine System
343
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
343
Pathophysiology of Diabetes
993
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
993
Overview of Lipid Metabolism
1.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.8K
