孕妇尿液甲酸盐度与妊娠期间血压之间的关联:系统性审查和元分析
Mengyue Zhang1,2, Jianchao Qiao1, Pinpeng Xie1
1Department of Clinical Medicine, The Second School of Clinical Medicine, Anhui Medical University, 81 Meishan Road, Hefei 230032, China.
Metabolites
|July 29, 2023
概括
这一元分析显示,包括MBP和MBzP在内的甲酸盐暴露与怀孕期间血压升高有关. 相反,MEHP暴露显示出负相关性,而MEP增加了妊娠高血压疾病 (HDP) 的风险.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 毒理学 毒理学 毒理学
背景情况:
- 酸盐是广泛存在的环境污染物,与有害健康影响有关.
- 之前对甲酸盐暴露和妊娠血压 (BP) 的研究已经产生了不确定的结果.
- 了解这些关联对于母亲和胎儿的福祉至关重要.
研究的目的:
- 进行一项元分析,以澄清妊娠期间甲酸盐暴露与血压之间的关系.
- 调查特定的甲酸代谢物及其与静缩血压,静缩血压和妊娠高血压障碍 (HDP) 的关联.
主要方法:
- 在PubMed,EMBASE和Web of Science进行了全面的文献搜索,搜索到2023年3月5日之前发表的研究.
- 随机效应模型被用来合成来自10项纳入研究的数据.
- 分析的重点是连续结果 (心缩和腹缩BP) 和二进制结果 (HDP).
主要成果:
- 第一个季度的单基甲酸盐 (MBP) 暴露与第二和第三季度的缩和腹缩血压有积极的关联.
- 第二个三个月的单基甲酸盐 (MBzP) 暴露与第三个月的高血压相关.
- 在第一季度暴露于单基-2-乙基基甲酸盐 (MEHP) 显示出与晚期三季度的血压有负面关联.
- 单乙烯甲酸盐 (MEP) 暴露与增加HDP的风险有关.
结论:
- 几种甲酸代谢物与高血压和怀孕期间增加HDP风险有关.
- 这些发现强调了孕妇暴露于环境甲酸盐的潜在风险.
- 需要进一步的研究来证实这些关联,并了解潜在的生物机制.
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