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肠道微生物群和脂肪组织微环境在肥胖中的相互作用
Congcong Wang1,2, Zihan Yi1,2, Ye Jiao1,2
1Chronic Disease Research Institute, The Children's Hospital, and National Clinical Research Center for Child Health, School of Public Health, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Metabolites
|July 29, 2023
概括
肠道微生物群,一个复杂的生态系统,在肥胖中发挥着关键作用. 肠道细菌及其代谢物的干扰会影响宿主代谢,导致过度的脂肪积累和肥胖的发展.
科学领域:
- 微生物学 微生物学
- 代谢过程中的代谢.
- 肥胖问题研究研究
背景情况:
- 肥胖是一个日益严重的全球健康问题.
- 肠道微生物群,一个多样化的微生物社区,调节宿主新陈代谢和能量平衡.
- 肠道微生物群组成的变化与肥胖的发展有关.
研究的目的:
- 综合审查肥胖症中的肠道微生物群变化.
- 总结微生物群衍生代谢物的功能作用.
- 要突出宿主组织和肠道微生物群在肥胖病原发生的双向相互作用.
主要方法:
- 关于肠道微生物群和肥胖的研究的文献综述.
- 对宿主微生物群相互作用的分析.
- 强调脂肪组织微环境的作用.
主要成果:
- 肠道微生物群的破坏有助于肥胖.
- 微生物群衍生代谢物影响宿主代谢.
- 主体组织通过各种信号通路调节肠道微生物群.
结论:
- 肠道微生物群及其代谢物在肥胖中起着至关重要的作用.
- 主体组织和肠道微生物群之间的双向相互作用是肥胖的核心.
- 脂肪组织微环境的相互作用在肥胖发作中尤为重要.
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