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乳球菌 (Lactococcus lactis) 亚种的免疫刺激活性乳糖 CAB701 从杰菜中分离出来的

Huijin Jeong¹, Suin Kim¹, Un-Sik Hwang²

¹Department of Food Science and Biotechnology, Gachon University, Seongnam-si 13120, Republic of Korea.

|July 29, 2023

概括

乳球菌乳酸菌 CAB701 显示出强大的益生菌潜力,具有出色的胃肠道存活率和抗氧化活性. 这种菌株通过增强氧化和炎症介质的产生,显著提高免疫反应.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
益生菌益生菌是一种益生菌.

背景情况:

益生菌细菌在胃肠道中需要强大的生存机制.
评估新型益生菌候选者的免疫刺激作用对于开发免疫增强疗法至关重要.

研究的目的:

为了评估Lactococcus lactis亚种的益生菌潜力. 牛奶糖 CAB701.1. 牛奶糖 CAB701. 牛奶糖 CAB701. 牛奶糖 CAB701. 牛奶糖 CAB701.
研究其生存能力,抗氧化活性和免疫刺激作用.

主要方法:

在酸性,胆性和胰腺素条件下评估生存率.
测量了抗氧化剂活性和粘附于Caco-2细胞.
在RAW 264.7细胞中分析了氧化的产生和炎症媒介的表达,包括MAPK通路的激活.

主要成果:

乳球菌乳酸菌亚种. 乳糖CAB701对胃肠道疾病有很高的耐受性和显著的抗氧化活性.
这种菌株在RAW 264.7细胞中显著增强了氧化的产生,超过了Lacticaseibacillus rhamnosus GG (LGG).
观察到可诱导的氧化合成酶,TNF-α,COX-2,IL-1β,IL-6和激活的MAPK信号通路 (JNK,ERK) 的表达升高.

结论:

乳球菌乳酸菌亚种. 乳糖 CAB701 具有显著的免疫刺激特性.
其强大的生存能力,抗氧化能力和强大的免疫调节效应使其成为旨在增强免疫反应的益生菌应用的有希望的候选人.

关键词:

乳球球菌 (lactococcus lactis) 是一种乳球菌.抗氧化剂活性抗氧化剂活性胃肠道的耐受性免疫刺激活动的免疫刺激活动.乳酸细菌是一种乳酸细菌.通过基因激活蛋白激酶途径.氧化生产生产的氧化益生菌是一种益生菌.

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