妊娠糖尿病与微生物组之间的关联:系统性审查和元分析
Rita Almeida Teixeira1, Cláudia Silva1, António Carlos Ferreira1
1Cardiovascular R&D Centre, UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Alameda Professor Hernani Monteiro, 4200-319 Porto, Portugal.
Microorganisms
|July 29, 2023
概括
妊娠期糖尿病 (GD) 与改变的肠道和胎盘微生物群有关. 这次审查发现,在GD中,Roseburia等特定细菌更常见,而Bifidobacterium则不太常见,影响母亲和婴儿的健康.
科学领域:
- 微生物学 微生物学
- 代谢健康 代谢健康
- 怀孕并发症 怀孕并发症
背景情况:
- 妊娠期糖尿病 (GD) 影响10%的怀孕,对母亲和婴儿造成健康风险.
- 身体的寄居微生物 (微生物群) 与代谢障碍有关.
- 了解GD中的微生物群差异对于开发有针对性的干预措施至关重要.
研究的目的:
- 系统地审查和对GD和健康对照的孕妇之间微生物群组成的差异进行元分析.
- 为了检查GD和没有GD的母亲的后代的微生物群变异.
- 评估与GD相关的胎盘和微生物群.
主要方法:
- 21项研究的系统审查和元分析.
- 在PubMed,Scopus和Web of Science数据库中进行的搜索.
- 对41个元分析进行分析,以综合有关微生物群组成的发现.
主要成果:
- 肠道微生物群:在GD中增加的Roseburia;在健康怀孕中增加的Bifidobacterium和Alistipes.
- 胎盘微生物群:GD中的Firmicutes增加;对照中的Proteobacteria增加,异质性较低.
- 麦科尼微生物群:在研究中观察到高异质性.
结论:
- 这些发现加强了微生物组与妊娠期糖尿病之间的联系.
- 肠道和胎盘中的特定微生物转移可能会导致GD病变.
- 针对微生物组的疗法显示出管理GD的潜力;需要进一步的研究和标准化的方法.
相关概念视频
Pathophysiology of Diabetes
993
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
993
Diabetes Mellitus: Type 2 and Gestational
2.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.5K
Anatomy of the Intestines
72.5K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.5K
Diabetes: Symptoms, Diagnosis, and Complications
593
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
593
Diabetes Mellitus: Overview and Type I Subtype
2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K
Glucose Transporters
22.9K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.9K


