在肠道中的Desulfovibrio:内心的敌人
Sudha B Singh1, Amanda Carroll-Portillo2, Henry C Lin2,3
1Biomedical Research Institute of New Mexico, Albuquerque, NM 87108, USA.
Microorganisms
|July 29, 2023
概括
减少硫酸盐的细菌Desulfovibrio (DSV) 可以在肠道中过度生长,并与各种疾病有关. 本综述探讨了它们在疾病病理学和潜在因果机制中的作用.
科学领域:
- 微生物学 微生物学
- 人类健康 人类健康 人类健康
- 肠道微生物组研究研究
背景情况:
- 脱硫纤维菌 (DSV) 是常见的硫酸盐减少细菌 (SRB),在环境和人类肠道中发现.
- 虽然通常是共生的,但DSV可以充当机会主义的病原生物,在疾病状态下过度生长.
- 越来越多的证据将DSV花与各种肠道和肠外疾病联系在一起.
研究的目的:
- 审查当前对DSV与人类疾病之间的关联的理解.
- 探索DSV可能导致疾病发展的潜在机制.
- 要突出DSV作为肠道中占主导地位的SRB属.
主要方法:
- 对调查Desulfovibrio和疾病的研究进行文献综述.
- 分析DSV过度生长和人类病理之间的相关性.
- 检查拟议的致病遗传机制.
主要成果:
- 在各种疾病期间,通常会发现DSV的数量增加.
- 有证据表明,DSV在疾病进展中的潜在因果作用.
- DSV是人类肠道中最丰富的SRB属.
结论:
- 过度生长的DSV与许多人类疾病有关.
- 需要进一步的研究来阐明DSV病原性的精确机制.
- 了解DSV的作用对于开发有针对性的治疗策略至关重要.
关键词:
这就是Desulfovibrio.帕金森病是帕金森氏症的一种疾病.硫化 (H2S) 是一种硫化.炎症性肠病是一种炎症性肠病.脂多糖 (LPS) 是一种脂多糖.硫酸盐还原细菌 (SRB) 是一种更多相关视频
相关概念视频
Bacterial Phylum Bacteroidota
44
The phylum Bacteroidota includes over 700 species classified into four primary orders: Bacteroidales, Cytophagales, Flavobacteriales, and Sphingobacteriales. These gram-negative, non-sporulating rods exhibit saccharolytic capabilities and can be aerobic or fermentative, encompassing obligate aerobes, facultative aerobes, and obligate anaerobes. Many species display gliding motility, though some are nonmotile or use flagella. The genus Bacteroides is well-studied due to its significant role in...
44
Bacterial Phylum Verrucomicrobiota
37
The phylum Verrucomicrobiota comprises at least four characterized orders, with most species classified within the order Verrucomicrobiotales. Members of this phylum are either aerobic or facultatively aerobic, with the ability to ferment sugars. A notable exception is the genus Methylacidiphilum, which consists of aerobic methanotrophs. Additionally, some Verrucomicrobiota establish symbiotic relationships with protists. These bacteria are widely distributed across various environments,...
37
Bacterial Flora of the Large Intestine
516
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
516
Bacterial Phylum Proteobacteria
42
Proteobacteria, one of the largest and most diverse bacterial phyla, encompasses a wide range of Gram-negative bacteria distinguished by their outer membrane composed of lipopolysaccharides. These microorganisms exhibit various metabolic capabilities, including phototrophy, chemolithotrophy, and heterotrophy, and thrive in diverse environments from soil to aquatic systems and host-associated niches. The phylum is divided into six classes: Alphaproteobacteria, Betaproteobacteria,...
42
Anoxygenic Phototrophic Bacteria
55
Anoxygenic phototrophic bacteria are a diverse group of microorganisms that perform photosynthesis without producing oxygen. They primarily include purple sulfur bacteria, purple nonsulfur bacteria, green sulfur bacteria, and green nonsulfur bacteria. These bacteria are classified into the Gammaproteobacteria, Alphaproteobacteria, Betaproteobacteria, Chlorobi, and Chloroflexi lineages, each with distinct physiological and ecological adaptations.Purple sulfur bacteria belong to the...
55
Sulfur Assimilation
45
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
45


