挥发性有机化合物评估作为早期检测胃肠道疾病的查工具
Costa Dalis1, Fikir M Mesfin1, Krishna Manohar1
1Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
改变的肠道细菌 (失生症) 可以标志着胃肠道疾病. 电子鼻子通过分析挥发性有机化合物 (VOC) 提供了一种更便宜,非侵入性的方法来检测这些疾病标志物.
科学领域:
- 胃肠道学和微生物组研究.
- 生物医学工程和传感器技术.
背景情况:
- 胃肠道 (GI) 疾病很普遍,但目前的查往往是侵入性的和昂贵的,导致诊断延迟和死亡率增加.
- 在许多胃肠道疾病中,肠道微生物组失生症在临床症状之前.
- 来自细菌代谢的挥发性有机化合物 (VOC) 是潜在的非侵入性肠道健康生物标志物.
研究的目的:
- 审查肠道失调在肠道疾病中的作用以及VOC代谢物作为诊断标记物的潜力.
- 总结目前用于检测肠道异常的VOC分析平台.
- 定义用于检测肠道疾病的电子鼻子 (E-nose) 技术的技术进步和局限性.
主要方法:
- 关于肠道微生物组,VOC分析和E鼻技术的科学文献的综述.
- 对头部空间VOC的分析,以检测肠道健康的变化.
- 对用于非侵入性胃肠道疾病查的E-鼻子设备的评估.
主要成果:
- 消化不良是各种胃肠道疾病的早期指标.
- 由肠道细菌产生的VOC可以通过非侵入性方法测量.
- 电子鼻子是一个有希望的,具有成本效益的,便携式的替代品,用于GI条件的传统诊断工具.
结论:
- 通过分析VOCs,电子鼻子显示出早期检测和预测胃肠道疾病的潜力.
- 需要进一步的研究和技术改进,才能在临床实践中全面实施E-nose技术.
- 通过E-noses进行非侵入性VOC检测可以彻底改变肠道疾病查和管理.
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