花 (Coriandrum sativum) 和其在精神疾病中的有用性
Anislada Santibáñez1,2, Enrique Jiménez-Ferrer1, Paola Isabel Angulo-Bejarano2
1Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1 Col Centro, Xochitepec 62790, Morelos, Mexico.
Molecules (Basel, Switzerland)
|July 29, 2023
概括
(Coriandrum sativum) 或,含有化合物,对中枢神经系统疾病具有潜在的治疗作用. 对其生物活性分子的进一步研究可能会导致治疗精神和神经疾病的新型植物药物.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 植物化学 植物化学
背景情况:
- 越来越多的精神疾病对全球福祉产生影响,需要开发新的药物.
- 目前的精神病药物有不良影响,导致停止治疗.
- (Coriandrum sativum) 是和黄的来源,其体外和体内活性已被证明与中枢神经系统疾病有关.
研究的目的:
- 审查从黄中分离出来的化合物的药理活性.
- 探索它们的治疗效果背后的机制.
- 建议未来的研究方向,以开发以黄为基础的植物药物.
主要方法:
- 关于Coriandrum sativum化合物的药理学研究的文献综述.
- 对已识别的化合物与神经目标 (例如GABA,5-HT,NMDA受体) 的相互作用进行分析.
- 探索技术方法,如分子对接和纳米粒子传递.
主要成果:
- 的化合物,特别是烯和黄,在体外和体内对中枢神经系统疾病模型表现出显著的活性.
- 某些化合物与关键的神经递质受体相互作用,这与精神病和神经疾病有关.
- 关于标准化黄提取物的临床数据有限,这表明研究缺口.
结论:
- 香中含有生物活性分子,具有潜在的抗焦虑,抗抑郁,抗和改善睡眠的特性.
- 需要对的化合物及其机制进行进一步的研究.
- 技术进步为开发新型植物药物从Coriandrum sativum用于中枢神经系统疾病提供了有希望的途径.
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