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使用天然深层欧特克溶剂绿色提取乌斯尼克酸的方法学方面

Magdalena Kulinowska¹, Sławomir Dresler^1,2, Agnieszka Skalska-Kamińska¹

¹Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, Poland.

Molecules (Basel, Switzerland)

|July 29, 2023

概括

这项研究探讨了天然的深层水溶剂 (NADESs) 用于酸 (UA) 提取,达到91%的产量. 这种NADES方法显著提高了这种有价值的化合物的传统酸提取效率.

科学领域:

自然产品化学自然产品化学
绿色化学绿色化学
提取技术提取技术

背景情况:

乌斯尼克酸 (UA) 是一种在中发现的生物活性化合物,在制药,化品,牙科和农业中具有应用.
目前的UA提取主要使用常规溶剂乙.
探索替代的,可持续的提取方法对于有效的UA隔离至关重要.

研究的目的:

为了研究乌斯尼克酸 (UA) 在各种天然深层维生素溶剂 (NADES) 中的溶解性.
通过实验设计方法优化UA提取使用甲基醇-坎NADES.
为了比较基于NADES的提取效率与传统的酸盐提取效率.

主要方法:

对UA溶解性的多个NADES的选.
优化UA提取使用甲基醇-坎NADES与实验设计方法的方法.
数字优化参数包括坎佛与蒂摩尔的比率 (0.3),液体与固体的比率 (60),和提取时间 (30分钟).

主要成果:

优化的NADES提取模型显示出预测值和实验值之间的良好一致性,偏差在11.93%至14.96%之间.
优化的NADES方法在单个步骤中实现了约91%的高UA提取产量.
乙提取在单个步骤中产生了明显较低的UA含量,仅为78.4%.

结论:

天然的深溶性溶剂,特别是甲基醇-坎混合物,为乌斯尼克酸提取提供了一种高效和优化的方法.
基于NADES的提取在产量和效率方面明显优于传统的乙提取.
这种优化的NADES方法提供了一种更绿色,更有效的替代方法,用于从自然来源中分离乌斯尼克酸.

关键词:

克拉多尼亚非正式的isis 实验的设计实验的设计绿色化学是一种绿色化学.类的水,类的水.自然产品是自然产品的产品.

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