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作为选择性COX-1抑制剂的m-Terphenylamines阻断了微质炎症反应,并发挥了神经保护作用

Damiano Rocchi1, Juan F González1, Olmo Martín-Cámara1

  • 1Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.

Molecules (Basel, Switzerland)
|July 29, 2023
PubMed
概括

使用新型m-terphenylamine衍生物选择性抑制循环氧化酶-1 (COX-1) 证明了显著的神经保护. 这些化合物有效地减少神经炎症和氧化应激,为急性脑疾病提供了有前途的治疗途径.

关键词:
这是一种COX-1抑制剂.神经炎症是一种神经炎症.神经保护神经保护氧化应激是一种氧化应激.烯胺类物质 (terphenylamines) 是一种烯胺类物质.

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