改变人类肠道微生物群的变化在饮食补充中使用改性大米阿拉伯诺基兰化合物
Emily Schupfer1, Soo Liang Ooi1, Thomas C Jeffries2
1School of Dentistry and Medical Sciences, Charles Sturt University, Bathurst, NSW 2795, Australia.
Molecules (Basel, Switzerland)
|July 29, 2023
概括
在健康成年人的个人肠道微生物中调节了米阿拉比诺基兰化合物 (RBAC) 补充剂. 生活方式和饮食显著影响了这些变化,突出了对RBAC的个性化反应.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 人类健康 人类健康 人类健康
背景情况:
- 肠道微生物群在人类健康中起着至关重要的作用.
- 饮食干预措施正在探索调节肠道微生物组成.
- 从大米中提取的阿拉比诺基兰化合物正在研究它们的益生菌潜力.
研究的目的:
- 为了研究一种改性大米阿拉比诺基兰化合物 (RBAC) 对健康成人的肠道微生物群的影响.
- 评估RBAC补充后微生物多样性和分类组合的变化.
- 探索RBAC剂量和个体因素对肠道微生物组调节的影响.
主要方法:
- 一项为期21周的研究,涉及10名健康成年人,消耗1g和3g的RBAC.
- 定期采集的便样本用于16S rRNA测序.
- 使用QIIME2对α和β多样性的分析,对个体反应和影响因素进行统计评估.
主要成果:
- 整体α或β多样性的显著变化与RBAC剂量或持续时间无关.
- 参与者的个性,饮食和生活方式显著影响了肠道微生物群的多样性 (p < 0.05).
- 在7名参与者中观察到显著的个人分类学变化,其中4人被确定为RBAC响应者.
结论:
- 肠道微生物组高度个性化.
- 补充RBAC可以调节肠道微生物群,反应因生活方式和饮食摄入量而异.
- 进一步的研究是有必要的,以了解个性化对预微生物干预措施的反应.
关键词:
澳大利亚推食品评分 澳大利亚推食品评分生物布兰/MGN-3 生物布兰RBAC RBAC RBAC RBAC RBAC RBAC RBAC RBAC RBAC RBAC RBAC RBAC RBAC RBAC RBAC RBAC RBAC RBAC饮食 饮食 饮食 饮食功能性食品是一种功能性食品.微生物组是一个微生物组.益生菌 益生菌前生物更多相关视频
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