在药物制剂中用电化学方法确定上腺素,使用拉波尼特粘土改性石墨烯喷墨印刷电极
Chancellin Nkepdep Pecheu1, Victor Kougoum Tchieda1, Kevin Yemele Tajeu1
1Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, Dschang P.O. Box 67, Cameroon.
Molecules (Basel, Switzerland)
|July 29, 2023
概括
这项研究介绍了一种用于检测上腺素 (EP) 的新型电化学传感器,该传感器是与神经退行性疾病相关的神经递质. 拉波尼特改性石墨烯电极为药品样本中的EP确定提供了增强的灵敏度和选择性.
科学领域:
- 电化学 电化学 电化学
- 材料科学 材料科学 材料科学
- 神经科学是一个神经科学.
背景情况:
- 上腺素 (EP) 是一种甲基醇胺神经递质,与阿尔茨海默氏症和帕金森氏症等神经退行性疾病有关.
- 对EP的敏感和选择性检测方法对于诊断和研究至关重要.
研究的目的:
- 开发和描述一个电压传感器,用于电分析检测EP.
- 为了提高EP检测,使用拉波尼特修饰的喷墨印刷石墨烯电极 (La/IPGE).
主要方法:
- 用拉波尼特 (La) 修改的喷墨印刷石墨烯电极 (IPGE) 的制造.
- 使用循环电压测量和电化学阻抗光谱学进行电化学表征.
- 使用微分脉冲电压测量对EP的量化.
主要成果:
- 与裸体IPGE (0.26μM与0.34μM) 相比,La/IPGE显示了更好的灵敏度和更低的EP检测极限.
- 在0.810μM范围内观察到EP度和峰值电流之间的线性关系.
- 该传感器具有很高的选择性,并成功地应用于制药中的EP测定.
结论:
- 开发的La/IPGE是用于EP检测的敏感和选择性的电化学传感器.
- 这种传感器有可能在现实世界样本中分析EP,包括药品.
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