尿酸和事件萨科佩尼亚之间的纵向关联
Shengliang Zhou1, Limin Wu1, Haibo Si1
1Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China.
Nutrients
|July 29, 2023
概括
高尿酸 (UA) 水平与中国老年男性患上肉症的风险降低有关,但女性并非如此. 这项研究探讨了在45岁以上的成年人中UA和新发 Sarcopenia 之间的关系.
科学领域:
- 老年学是指老年学的学科.
- 代谢健康 代谢健康
- 肌肉骨研究 研究
背景情况:
- 萨科佩尼亚是老龄化人口中日益严重的公共卫生问题.
- 尿酸 (UA) 是一种抗氧化剂代谢物,已显示与肉类的关联,但因果关系尚不清楚.
- 研究UA和发生的肉症之间的纵向关系对于了解其在衰老中的作用至关重要.
研究的目的:
- 为了检查尿酸水平与肉类的发病率之间的纵向关联.
- 为了探索UA和萨科佩尼亚之间的关系中的潜在性别差异.
- 为了解影响年龄相关肌肉损失的代谢因素提供见解.
主要方法:
- 利用来自中国健康与退休长度研究 (CHARLS) 的5086名年龄≥45岁的参与者的数据.
- 分析的尿酸 (UA) 水平分为性别特定的四分位数和连续变量 (每1 mg/dL).
- 采用了Cox比例危险回归模型来评估UA和发生的肉类之间在4年后续的纵向关联.
主要成果:
- 在随访期间确定了552例 (10.85%) 发生的萨科佩尼亚病例.
- 在男性中,较高的UA水平 (Q3和Q4) 与较低的发生肉类的风险显著相关 (HR分别为0.72和0.57).
- 当UA连续分析时 (HR 0.87),男性的反向关联持续存在,女性没有发现显著的关联.
结论:
- 尿酸与中老年和老年中国男性发生的肉症有负面关联.
- 该研究没有发现尿酸水平与女性发生的肉类之间存在显著的关联.
- 这些发现表明UA在老年男性中可能有保护性作用,可以防止肉症的发生.
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