通过低热量均衡饮食调节人类肠道微生物群:一种有效的方法来管理肥胖
Hongchao Wang1,2, Wenyan Song1,2, Weiwei Yuan1,2
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
Nutrients
|July 29, 2023
概括
低热量均衡饮食 (HBD) 显著降低了BMI,并改变了肥胖个体的肠道微生物群. 成功减肥与更健康的肠道微生物组组成相关.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 肥胖研究 肥胖研究
背景情况:
- 肥胖是一个复杂的健康问题,对代谢健康有重大影响.
- 肠道微生物群在宿主新陈代谢和体重调节中起着至关重要的作用.
- 饮食干预是管理肥胖及其相关健康风险的关键策略.
研究的目的:
- 研究低热量均衡饮食 (HBD) 对肥胖个体的人类测量和肠道微生物群组成的影响.
- 为了确定与成功减肥相关的肠道细菌的特定变化.
- 探索饮食诱导的减肥和肠道微生物组变化之间的关系.
主要方法:
- 对43名肥胖参与者实施了为期12周的低热量均衡饮食 (HBD) 干预措施.
- 人类测量测量 (包括BMI) 和便样本在基线和第12周收集.
- 用16SrRNA基因测序分析了肠道微生物组成,并使用机器学习模型进行特征重要性分析.
主要成果:
- 乙型肝炎干预导致BMI和其他生理指标显著降低,特别是在有效乙型肝炎组 (EHBD) 中,体重减轻≥5%.
- 在包括Blautia,Lachnoclostridium,Terrisporobacter,Ruminococcus (R. torques,R. gnavus) 和Pseudomonas.在内的细菌属中观察到显著的减少.
- 机器学习确定了前10个关键细菌属,肠道微生物群的共同存在网络表明,转向更健康的特征,成功减肥.
结论:
- 低热量均衡饮食 (HBD) 有效促进体重减轻和改善肥胖患者的人类测量指标.
- 肝炎干预显著调节肠道微生物群的组成,使特定的细菌种类减少.
- 通过HBD获得的饮食诱导的体重减轻与肠道微生物群的有利变化有关,这表明存在潜在的机械联系.
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