在补充养期间多不和脂肪酸摄入量和非常低出生体重婴儿的神经发育结果
Melanie Gsoellpointner1, Margarita Thanhaeuser2, Fabian Eibensteiner2
1Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Nutrients
|July 29, 2023
概括
在补充养期间摄入更多的多不和脂肪酸 (PUFAs),包括多和酸 (DHA) 和酸 (AA),与非常低出生体重婴儿的神经发育的改善有关. 然而,目前的摄入量往往低于推水平.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 儿科 儿科 儿科
背景情况:
- 多不和脂肪酸 (PUFA) 对婴儿大脑发育至关重要.
- 关于补充养 (CF) 期间的PUFA摄入量及其在非常低出生体重 (VLBW) 婴儿的神经发育影响的数据有限.
研究的目的:
- 检查在CF期间饮食中摄入的PUFA,阿拉基酸 (AA) 和docosahexaenoic acid (DHA) 与VLBW婴儿的神经发育结果之间的关联.
- 为了评估12个月和24个月的神经发育,校正年龄 (CA).
主要方法:
- 一个随机干预试验的二次分析.
- 饮食摄入量通过每月3天的方案 (3-12个月CA) 来评估.
- 使用贝利婴儿发育尺度-III.III评估的神经发育.
主要成果:
- 较高的PUFA和DHA总摄入量与12个月CA后改善的认知和运动功能相关.
- 增加AA摄入量与12个月CA后增强的运动分数有关.
- 在整个研究期间,AA和DHA摄入量的中位数低于推水平.
结论:
- 在CF期间增加总PUFA,DHA和AA摄入量对于VLBW婴儿至关重要.
- 满足推摄入水平可能会优化这种脆弱人群的神经发育结果.
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