腹腔透析患者的酸盐控制:问题,解决方案和开放问题
Valeria Cernaro1, Michela Calderone1, Guido Gembillo1
1Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Nutrients
|July 29, 2023
概括
在腹腔透析的晚期慢性病患者中管理高酸血是复杂的. 有效的酸盐控制需要考虑饮食,残留功能和透析策略的多方面的方法.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内部医学 内部医学
- 临床药房 临床药房
背景情况:
- 高酸血症在晚期慢性病 (CKD) 中很普遍,增加了心血管风险.
- 腹腔透析 (PD) 患者的酸盐管理具有挑战性,因为酸盐作为中等大小的分子的行为具有挑战性.
- 目前的治疗策略通常依赖于血液透析试验的数据,对PD患者群体的研究有限.
研究的目的:
- 审查在接受腹腔透析的尿性患者中高酸血症的管理.
- 突出影响PD患者酸盐控制的因素.
- 发现当前研究中的差距,并倡导针对PD的特定临床试验.
主要方法:
- 对PD中高酸血症管理现有文献的叙述性综述.
- 分析影响PD期间酸盐去除的因素,包括患者运输器和透析处方.
- 检查饮食,酸盐结合剂和功能残留的作用.
主要成果:
- 酸腹膜去除通常是不够的,特别是在具有较低输送器特征的患者中.
- 限制饮食和预防营养不良是管理的关键组成部分.
- 剩余功能在维持酸盐平衡方面发挥着重要作用.
结论:
- 血清酸盐控制不足在PD患者中很常见,这突显了治疗挑战.
- 需要一种综合治疗方法,包括饮食,结合剂和优化PD.
- 需要大规模,精心设计的临床试验,专门针对PD患者,以指导最佳管理和改善临床结果.
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