秘鲁艾滋病毒感染者和艾滋病毒/HTLV-1 同时感染患者之间的社会人口,临床和死亡率差异
Maria Pia Amanzo-Vargas1,2, Tessy Arellano-Veintemilla1, Elsa González-Lagos1,2
1Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima 15102, Peru.
Pathogens (Basel, Switzerland)
|July 29, 2023
概括
人类免疫缺陷病毒 (HIV) 和人类T淋巴细胞病毒-1 (HTLV-1) 的同时感染显著缩短了生存时间. 这项研究强调了同时感染患者的死亡风险增加,强调了进一步研究的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 秘鲁艾滋病毒/HTLV-1联合感染的高患病率 (高达18%).
- 关于HTLV-1同时感染对艾滋病毒患者的影响的研究有限.
- 秘鲁的HTLV-1特有性需要了解共感染效应.
研究的目的:
- 比较艾滋病毒与HIV/HTLV-1同时感染的患者的社会人口和临床特征.
- 分析两组患者之间的死亡率.
- 评估HIV/HTLV-1同时感染对患者存活时间的影响.
主要方法:
- 在利马 (1989-2019) 的艾滋病毒和HTLV-1队列的回顾性医疗记录审查.
- 根据性别,年龄和艾滋病毒诊断年份,将同时感染的患者与感染艾滋病毒的对照 (1:2比) 相匹配.
- 采用概率敏感性分析来解决潜在的HTLV-1暴露错误分类偏差.
主要成果:
- 艾滋病毒/HTLV-1同时感染与11.8倍的死亡风险增加有关 (HR:11.8;95% CI:1.55-89.00;p=0.017).
- 抗逆转录病毒治疗显著降低了死亡风险 (HR:0.03;95% CI:0.003-0.25;p=0.001).
- 同时感染的患者的平均存活时间为14.19年,而HIV感染的患者的平均存活时间为23.83年 (p < 0.001).
结论:
- 同时感染HIV/HTLV-1的患者的生存时间显著缩短.
- HTLV-1诱导的免疫变化可能会损害CD4计数,延迟ART启动并减少预防的好处.
- 这些发现强调了HTLV-1对艾滋病毒患者结果的关键影响.
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