在2020年期间,在黎巴嫩的蝙蝠中检测到冠状病毒
Ahmed Kandeil1,2,3, Mounir Abi-Said4, Rebecca Badra3
1Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Pathogens (Basel, Switzerland)
|July 29, 2023
概括
黎巴嫩的蝙蝠携带各种冠状病毒 (CoV),包括类似SARS的菌株. 这些病毒对人类的ACE2受体表现出高效的结合,这表明有显著的动物感染潜力.
科学领域:
- 病毒学 病毒学
- 动物传播疾病 动物传播疾病
- 蝙蝠生态学蝙蝠生态学
背景情况:
- 蝙蝠是冠状病毒 (CoV) 的主要储库,包括那些负责SARS-CoV和SARS-CoV-2的病毒.
- 以前的研究表明,蝙蝠在严重急性呼吸综合征冠状病毒的出现中发挥了至关重要的作用.
- 在全球范围内,在蝙蝠种群中越来越多地检测到类似SARS-CoV的病毒.
研究的目的:
- 在黎巴嫩的蝙蝠种群中对冠状病毒进行监测.
- 在黎巴嫩蝙蝠中传播的冠状病毒的识别和遗传特征.
- 通过尖端蛋白与受体相互作用来评估检测到的类似SARS的冠状病毒的动物感染潜力.
主要方法:
- 2020年在黎巴嫩对六种不同的蝙蝠物种的监测.
- 收集和分析了622个抽样样本.
- 使用分子方法识别Alpha和Beta冠状病毒.
- 尖端蛋白质受体结合域的3D蛋白质结构分析.
主要成果:
- 在622个扫描样本中,有77个对冠状病毒呈阳性.
- 在各种蝙蝠物种中确定了α和β冠状病毒.
- 检测到的类似SARS的冠状病毒对人类的ACE2受体表现出高效的结合,在结合亲和力方面超过了SARS-CoV-2.
- 已识别的类似SARS病毒的尖端蛋白质缺乏裂变部位的furin识别部位.
结论:
- 黎巴嫩的蝙蝠宿主各种各样的冠状病毒,包括类似SARS的菌株.
- 该地区蝙蝠冠状病毒的遗传多样性很大.
- 这些病毒对人类ACE2受体的有效结合突显了它们的动物感染潜力.
- 对蝙蝠冠状病毒相互作用的进一步研究对于了解潜在的流行病起源至关重要.
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