微生物与农业生态系统中的微塑料和纳米塑料的相互作用 - - 对抗菌素耐药性的影响
Jayashree Nath1, Jayita De1, Shantanu Sur2
1Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Pathogens (Basel, Switzerland)
|July 29, 2023
概括
微塑料和纳米塑料加速了细菌之间的抗微生物耐药性基因转移. 了解这些微纳米塑料相互作用对于应对抗菌素耐药性的全球公共卫生威胁至关重要.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 微塑料 (MP) 和纳米塑料 (NP) 作为抗微生物耐药性基因 (ARG) 的载体,促进它们在细菌物种之间交换.
- 抗微生物耐药性 (AMR) 的传播是一个重大的全球健康问题,由微纳米塑料 (MNP) 的影响下水平基因转移 (HGT) 加剧.
- 在土壤和水等环境中MNP的存在会改变微生物的基因表达,影响本地微生物群,它们的抗体和生态系统健康.
研究的目的:
- 审查有关MNP-微生物相互作用及其在HGT和AMR中的作用的当前知识.
- 要突出在复杂矩阵中量化MNP污染的挑战.
- 提高人们对由于MNP增加ARG传播的可能性的认识.
主要方法:
- 对MNP-微生物相互作用现有研究的文献综述.
- 在MNP压力下分析影响HGT和AMR的因素.
- 讨论复杂矩阵MP检测方法的最新进展.
主要成果:
- MNPs增强了辅助污染物的吸附,增加了微生物的暴露,改变了AMR,毒性和毒素的产生.
- 缺乏从有机丰富基质中提取和检测MNP的标准化协议,这阻碍了准确的污染评估.
- 最近的检测方法进步显示出对量化MNP污染的前景.
结论:
- 多种NP-微生物相互作用显著影响ARG和AMR的传播.
- 需要进一步的研究和标准化的方法来理解和减轻MNP驱动的AMR.
- 意识到MNP的影响对于防止未来出现多药耐药细菌至关重要.
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