输血医学中的新兴病原体威胁:提高对病原体减少技术的安全性和信心
Marcia Cardoso1, Izabela Ragan2, Lindsay Hartson3
1Terumo BCT, Inc., TERUMO Böood and Cell Technologies, Zaventem, 41 1930 Brussels, Belgium.
Pathogens (Basel, Switzerland)
|July 29, 2023
概括
新出现的传染病带来了输血风险. 米拉索尔的病原体减少技术 (PRT) 系统,使用利博弗拉和紫外线,有效地降低了各种血液传播病原体的传播风险.
科学领域:
- 传染性疾病 传染性疾病
- 血液安全 血液安全
- 公共卫生 公共卫生
背景情况:
- 新出现的传染病威胁正在增加,原因是全球因素,如气候变化和增加的人与动物的接触.
- 输血虽然至关重要,但仍有传播捐献血液中存在的传染病原体的风险.
- 易受伤害的群体尤其面临输血传染病的风险.
研究的目的:
- 审查病原体减少方法在预防输血传播感染方面的有效性.
- 评估米拉索尔PRT系统作为对新出现的传染病原体的积极措施.
- 评估Mirasol PRT系统对特定新出现的威胁的实时有效性.
主要方法:
- 这篇评论侧重于米拉索尔PRT系统,这是一种利用 riboflavin 和紫外线的光化学方法.
- 评估米拉索尔PRT系统对埃博拉,SARS-CoV-2,E型肝炎和mopox等新兴病原体的有效性.
- 对血液制品中的病原体减少实时数据的评估.
主要成果:
- 米拉索尔的PRT系统在降低各种新兴传染病原体的传播风险方面已经证明了其有效性.
- 光化学方法在减轻输血相关风险方面表现有前途,即使是针对新型病原体.
- 实时评估证实了系统应对当前和新兴威胁的能力.
结论:
- 积极的病原体减少方法,如米拉索尔PRT系统,对于提高血液安全至关重要.
- 米拉索尔PRT系统提供了一种可行的解决方案,以最大限度地降低来自新出现的病原体的输血传播感染的风险.
- 持续实施和评估病原体减少技术对于全球卫生安全至关重要.
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