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之前的乌苏图病毒感染可以保护免受西尼罗河病的严重影响

Hannah Reemtsma¹, Cora M Holicki¹, Christine Fast¹

¹Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, 17493 Greifswald-Insel Riems, Germany.

Pathogens (Basel, Switzerland)

|July 29, 2023

概括

之前的乌苏图病毒 (USUV) 感染可能会保护免受西尼罗河病毒 (WNV) 严重疾病的影响. 在USUV后连续感染WNV导致的病毒载量降低,病理不那么严重.

科学领域:

兽医病毒学兽医病毒学
病原体干扰病原体干扰
鸟类免疫学鸟类免疫学

背景情况:

乌苏图病毒 (USUV) 和西尼罗病毒 (WNV) 是相关的黄病毒,宿主重叠,在中欧地区分布.
了解它们在单一宿主中的相互作用对于评估疾病风险至关重要.

研究的目的:

在使用的顺序感染模型中研究USUV和WNV之间的放大潜力和干扰.
为了评估之前的USUV感染对随后的WNV挑战的保护作用.

主要方法:

两周大的被USUV感染,然后17天后被WNV感染.
在血液和抽样样本以及器官组织中检测病毒RNA.
组织病理学检查器官的病变,包括脑炎和状腺炎.

主要成果:

对USUV和WNV都产生了抗体.
在感染USUV的的血液,拭子和器官中检测到USUV,并与此相关的脑炎和状腺炎.
与WNV单一感染相比,USUV后的顺序性WNV感染导致WNV基因组副本数量显著降低,并减少了他的病理病变.

结论:

之前的USUV感染为提供了一定程度的保护,防止随后的WNV感染.
美国紫外线感染可以减少易受感染的鸟类宿主中的WNV放大和疾病严重程度.

关键词:

德国德国德国德国乌苏图病毒是一种病毒.西尼罗河病毒病毒.共同保护共同保护实验性感染的试验.弗拉维病毒 (flavivirus) 是一种病毒.子子子

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Viral Recombination

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.