通过TREM2信号通路,EVOO多对微细胞产生抗炎作用
Manuela Leri1, Marzia Vasarri1, Federica Carnemolla1
1Dipartimento di Scienze Biomediche Sperimentali e Cliniche "Mario Serio", Università degli Studi di Firenze, 50134 Firenze, Italy.
Pharmaceuticals (Basel, Switzerland)
|July 29, 2023
概括
橄油多通过激活TREM2通路并促进保护性微质活性来降低神经炎症. 这些发现强调了饮食中的橄多.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 微质,大脑的免疫细胞,在阿尔茨海默氏症 (AD) 中成为慢性炎症,导致神经毒性.
- 像TREM2这样的微质病相关分子中的遗传变异增加了AD风险和认知能力下降.
- 神经炎症是阿尔茨海默病研究的一个关键领域.
研究的目的:
- 为了研究额外处女橄油 (EVOO) 聚的神经保护作用,特别是油脂蛋白甘 (OleA) 和酸 (HT).
- 阐明EVOO多在体外调节微质活动和神经炎症的机制.
主要方法:
- 在体外测试中使用人类神经元 (SH-SY5Y) 和微质细胞 (BV2,C13NJ) 细胞模型.
- 用EVOO多 (OleA,HT) 进行治疗,然后进行脂多糖 (LPS) 刺激.
- 使用ELISA,MTT测定,ROS检测,西斑和免疫光检测来评估保护作用.
主要成果:
- 乙烯聚醇显著降低了促炎性细胞因子 (IL-6,IL-8,IP-10,RANTES) 的释放.
- 聚醇激活了TREM2依赖的抗炎途径.
- 增强微质活动和促进M2极化,表明向保护性表型的转变.
结论:
- 饮食中的橄多通过减轻神经炎症和神经元损伤来发挥神经保护作用.
- 该研究提供了关于EVOO多如何通过TREM2.调节微质功能的机制性见解.
- 这些发现支持饮食橄多在对抗与阿尔茨海默氏症相关的神经炎症方面的有益作用.
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